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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P25322 (2 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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A-kinase anchor protein 12 (Mus)G1/S-specific cyclin-D1 (Mus)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

A-kinase anchor protein 12 - Akap12 -  Mus musculus
DOC_CYCLIN_1501504BinaryPhysicochemical compatibilityPhosphorylation of S507 adjacent to the cyclin-binding motif of A-kinase anchor protein 12 (Akap12) by PKC subfamily blocks binding to the G1/S-specific cyclin-D1 (Ccnd1). As a result, the function of A-kinase anchor protein 12 (Akap12) as a scaffold is inhibited and G1/S-specific cyclin-D1 (Ccnd1) is translocated to the nucleus where it regulates progression of the cell cycle from G1 to S phase.
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G1/S-specific cyclin-D1 - Ccnd1 -  Mus musculus
DOC_WW_Pin1_4283288BinaryPhysicochemical compatibilityPhosphorylation of T286 in the Pin1-binding motif of G1/S-specific cyclin-D1 (Ccnd1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.
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