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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF00928 (9 hits) x
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AP2-associated protein kinase 1Cyclin-dependent kinase 5 (Mus)Proto-oncogene tyrosine-protein kinase LCK (Mus)
Proto-oncogene tyrosine-protein kinase SrcTyrosine-protein kinase Fyn (Mus)Tyrosine-protein kinase JAK2
Tyrosine-protein kinase Lck


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

AP2-associated protein kinase 1 - AAK1 -  Homo sapiens
TRG_ENDOCYTIC_2 PPAL_HUMAN413416UncategorisedUncategorisedPhosphorylation of T156 in AP-2 complex subunit mu (AP2M1) by AP2-associated protein kinase 1 (AAK1) upon clathrin recruitment strengthens the interaction between AP-2 complex subunit mu (AP2M1) and cargo proteins.
details
Curated

Cyclin-dependent kinase 5 - CDK5 -  Mus musculus
TRG_ENDOCYTIC_2 PI51C_HUMAN649652BinaryPhysicochemical compatibilityPhosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).
details
Curated

Proto-oncogene tyrosine-protein kinase LCK - LCK -  Mus musculus
TRG_ENDOCYTIC_2 CTLA4_MOUSE201204SpecificityAltered binding specificityDephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.
details
Inferred

Proto-oncogene tyrosine-protein kinase Src - SRC -  Homo sapiens
TRG_ENDOCYTIC_2 L1CAM_HUMAN11761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 by Proto-oncogene tyrosine-protein kinase Src (SRC) in the endocytosis motif of Neural cell adhesion molecule L1 (L1CAM) inhibits binding to AP-2 complex subunit mu (AP2M1).
details
Curated
TRG_ENDOCYTIC_2 L1CAM_HUMAN11761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).
details
Curated

Tyrosine-protein kinase Fyn - FYN -  Mus musculus
TRG_ENDOCYTIC_2 CTLA4_MOUSE201204SpecificityAltered binding specificityDephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.
details
Inferred

Tyrosine-protein kinase JAK2 - JAK2 -  Homo sapiens
TRG_ENDOCYTIC_2 CTLA4_MOUSE201204SpecificityAltered binding specificityDephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.
details
Inferred
TRG_ENDOCYTIC_2 CTLA4_MOUSE201204SpecificityAltered binding specificityDephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.
details
Inferred

Tyrosine-protein kinase Lck - LCK -  Homo sapiens
TRG_ENDOCYTIC_2 CTLA4_MOUSE201204SpecificityAltered binding specificityDephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.
details
Inferred
           
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