About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P16333 (7 hits) x
submit


x  Coloured by: Modifier evidence source
          Curated          inferred


x  Index
Ephrin type-A receptor 3Epidermal growth factor receptorProto-oncogene tyrosine-protein kinase Src
RAC subfamily ()Tyrosine-protein kinase ABL1cGMP-dependent protein kinase 1


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

RAC subfamily
LIG_SH3_2 PAK1_HUMAN1318BinaryPhysicochemical compatibilityPhosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.
details
Curated

Ephrin type-A receptor 3 - EPHA3 -  Homo sapiens
LIG_SH2_IA EPHA3_HUMAN597606BinaryPhysicochemical compatibilityPhosphorylation of Y602 in the SH2-binding motif of Ephrin type-A receptor 3 (EPHA3) induces binding to the Cytoplasmic protein NCK1 (NCK1) protein.
details
Inferred

Epidermal growth factor receptor - EGFR -  Homo sapiens
LIG_SH2_SRC EGFR_HUMAN10161019BinaryPhysicochemical compatibilityPhosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Cytoplasmic protein NCK1 (NCK1).
details
Inferred

Proto-oncogene tyrosine-protein kinase Src - SRC -  Homo sapiens
LIG_SH2_SRC EGFR_HUMAN10161019BinaryPhysicochemical compatibilityPhosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Cytoplasmic protein NCK1 (NCK1).
details
Inferred
LIG_SH2_SRC EGFR_HUMAN10161019BinaryPhysicochemical compatibilityPhosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Cytoplasmic protein NCK1 (NCK1).
details
Inferred

Tyrosine-protein kinase ABL1 - ABL1 -  Homo sapiens
LIG_SH2_SRC EGFR_HUMAN10161019BinaryPhysicochemical compatibilityPhosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Cytoplasmic protein NCK1 (NCK1).
details
Inferred

cGMP-dependent protein kinase 1 - PRKG1 -  Homo sapiens
LIG_SH3_2 PAK1_HUMAN1318BinaryPhysicochemical compatibilityPhosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.
details
Inferred
           
Please send any suggestions/comments to: switches@elm.eu.org