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Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P22681 (15 hits) x

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Curated inferred

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Calcium/calmodulin-dependent protein kinase type II subunit alpha	Calcium/calmodulin-dependent protein kinase type II subunit alpha (Rattus)	Insulin receptor (Rattus)
Proto-oncogene tyrosine-protein kinase Src	Tyrosine-protein kinase ABL1 (Mus)	Tyrosine-protein kinase Fyn
Tyrosine-protein kinase Lck	Tyrosine-protein kinase SYK	Tyrosine-protein kinase Yes

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Protein

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Evidence

Calcium/calmodulin-dependent protein kinase type II subunit alpha - CAMK2A - Homo sapiens
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
Calcium/calmodulin-dependent protein kinase type II subunit alpha - CAMK2A - Rattus norvegicus
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
Insulin receptor - INSR - Rattus norvegicus
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_TKB	SPY2_HUMAN	55	60	Binary	Physicochemical compatibility	Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	SPY2_HUMAN	55	60	Binary	Physicochemical compatibility	Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Tyrosine-protein kinase ABL1 - ABL1 - Mus musculus
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Tyrosine-protein kinase Lck - LCK - Homo sapiens
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Tyrosine-protein kinase SYK - SYK - Homo sapiens
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Tyrosine-protein kinase Yes - YES1 - Homo sapiens
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred