switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P22681 (8 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Endocytosis	ErbB signaling pathway	Insulin signaling pathway
Jak-STAT signaling pathway

Motif

Protein

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End

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Information

Evidence

Endocytosis (KEGG - hsa04144)
LIG_TKB	EGFR_HUMAN	1069	1074	Binary	Physicochemical compatibility	Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_TKB	EGFR_HUMAN	1069	1074	Binary	Physicochemical compatibility	Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Insulin signaling pathway (KEGG - hsa04910)
LIG_SH2_IB	CBL_HUMAN	770	780	Binary	Physicochemical compatibility	Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.	details	Inferred
Jak-STAT signaling pathway (KEGG - hsa04630)
LIG_TKB	SPY2_HUMAN	55	60	Binary	Physicochemical compatibility	Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	SPY2_HUMAN	55	60	Cumulative	Rheostatic	While phosphorylation of Y55 induces binding, additional phosphorylation of T56 in the TKB-binding motif of Protein sprouty homolog 2 (SPRY2) lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred