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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P22681 (15 hits) x


x  Coloured by: Modifier evidence source
          Curated          inferred


x  Index
Calcium/calmodulin-dependent protein kinase type II subunit alphaCalcium/calmodulin-dependent protein kinase type II subunit alpha (Rattus)Insulin receptor (Rattus)
Proto-oncogene tyrosine-protein kinase SrcTyrosine-protein kinase ABL1 (Mus)Tyrosine-protein kinase Fyn
Tyrosine-protein kinase LckTyrosine-protein kinase SYKTyrosine-protein kinase Yes


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Calcium/calmodulin-dependent protein kinase type II subunit alpha - CAMK2A -  Homo sapiens
LIG_TKB EGFR_HUMAN10691074CumulativeRheostaticWhile phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
LIG_TKB EGFR_HUMAN10691074CumulativeRheostaticWhile phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred

Calcium/calmodulin-dependent protein kinase type II subunit alpha - CAMK2A -  Rattus norvegicus
LIG_TKB EGFR_HUMAN10691074CumulativeRheostaticWhile phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
LIG_TKB EGFR_HUMAN10691074CumulativeRheostaticWhile phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred

Insulin receptor - INSR -  Rattus norvegicus
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred

Proto-oncogene tyrosine-protein kinase Src - SRC -  Homo sapiens
LIG_TKB SPY2_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
LIG_TKB SPY2_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred

Tyrosine-protein kinase ABL1 - ABL1 -  Mus musculus
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred

Tyrosine-protein kinase Fyn - FYN -  Homo sapiens
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred

Tyrosine-protein kinase Lck - LCK -  Homo sapiens
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred

Tyrosine-protein kinase SYK - SYK -  Homo sapiens
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred

Tyrosine-protein kinase Yes - YES1 -  Homo sapiens
LIG_SH2_IB CBL_HUMAN770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details
Inferred
           
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