switches.ELM

3-phosphoinositide-dependent protein kinase 1 - PDPK1 - Homo sapiens
LIG_14-3-3_1	M3K5_HUMAN	963	968	Binary	Physicochemical compatibility	Phosphorylation of S966 in the 14-3-3-binding motif of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. This interaction inhibits the pro-apoptotic activity of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5).	details	Inferred
PKC subfamily
LIG_14-3-3_2	PDE3A_HUMAN	424	430	Binary	Physicochemical compatibility	Phosphorylation of S428 by in the 14-3-3-binding motif of cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.	details	Curated
Mitogen-activated protein kinase kinase kinase 5 - MAP3K5 - Homo sapiens
LIG_14-3-3_1	M3K5_HUMAN	963	968	Binary	Physicochemical compatibility	Phosphorylation of S966 in the 14-3-3-binding motif of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. This interaction inhibits the pro-apoptotic activity of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5).	details	Inferred
LIG_14-3-3_1	M3K5_HUMAN	963	968	Binary	Physicochemical compatibility	Phosphorylation of S966 in the 14-3-3-binding motif of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. This interaction inhibits the pro-apoptotic activity of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5).	details	Inferred
Protein kinase C alpha type - PRKCA - Homo sapiens
LIG_14-3-3_2	PDE3A_HUMAN	424	430	Binary	Physicochemical compatibility	Phosphorylation of S428 by in the 14-3-3-binding motif of cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.	details	Inferred
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
Protein kinase C beta type - PRKCB - Homo sapiens
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
Protein kinase C beta type - PRKCB - Homo sapiens
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
Protein kinase C delta type - PRKCD - Homo sapiens
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
Protein kinase C eta type - PRKCH - Homo sapiens
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
LIG_14-3-3_3	ITB2_HUMAN	755	760	Specificity	Altered binding specificity	Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).	details	Inferred
RAC-alpha serine/threonine-protein kinase - AKT1 - Homo sapiens
LIG_14-3-3_1	ATX1_HUMAN	772	777	Binary	Physicochemical compatibility	Phosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.	details	Curated
LIG_14-3-3_2	FOXO4_HUMAN	193	199	Binary	Physicochemical compatibility	Phosphorylation of S197 by in the 14-3-3-binding motif of Forkhead box protein O4 (FOXO4) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.	details	Curated
LIG_14-3-3_1	ATX1_HUMAN	772	777	Specificity	Altered binding specificity	Phosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation.	details	Inferred
cAMP-dependent protein kinase catalytic subunit alpha - PRKACA - Homo sapiens
LIG_14-3-3_1	ATX1_HUMAN	772	777	Binary	Physicochemical compatibility	Phosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.	details	Inferred
LIG_14-3-3_1	ATX1_HUMAN	772	777	Specificity	Altered binding specificity	Phosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation.	details	Inferred

3-phosphoinositide-dependent protein kinase 1	Mitogen-activated protein kinase kinase kinase 5	PKC subfamily ()
Protein kinase C alpha type	Protein kinase C beta type	Protein kinase C beta type
Protein kinase C delta type	Protein kinase C eta type	RAC-alpha serine/threonine-protein kinase
cAMP-dependent protein kinase catalytic subunit alpha