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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Protein | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
LIG_SH2_IB - | |||||||
| DOK1_HUMAN | 447 | 454 | Binary | Physicochemical compatibility | Phosphorylation of Y449 in the SH2-binding motif of Docking protein 1 (DOK1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein. | ||
| SLAF1_HUMAN | 276 | 286 | Binary | Physicochemical compatibility | Phosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein. | ||
LIG_TYR_ITSM - ITSM (immunoreceptor tyrosine-based switch motif). This motif is present in the cytoplasmic region of the CD150 subfamily within the CD2 family and it enables these receptors to bind to and to be regulated by SH2 adaptor molecules, as SH2DIA. | |||||||
| SLAF7_HUMAN | 280 | 287 | Binary | Pre‑translational | Alternative splicing removes the ITSM (immunoreceptor tyrosine-based switch motif) motif of SLAM family member 7 (SLAMF7), abrogating binding to SH2 domain-containing protein 1A (SH2D1A). The full-length isoform (Isoform CS1-L of SLAM family member 7 (SLAMF7)) has 2 ITSM motifs and only one is missing in the shorter splice variant (Isoform 19A24 of SLAM family member 7 (SLAMF7)). However, experiments showed only Isoform CS1-L of SLAM family member 7 (SLAMF7) binds to SH2D1A. | ||