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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:O60880 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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Docking protein 1SLAM family member 7Signaling lymphocytic activation molecule


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Docking protein 1 - DOK1 -  Homo sapiens
LIG_SH2_IB447454BinaryPhysicochemical compatibilityPhosphorylation of Y449 in the SH2-binding motif of Docking protein 1 (DOK1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein.
details

SLAM family member 7 - SLAMF7 -  Homo sapiens
LIG_TYR_ITSM280287BinaryPre‑translationalAlternative splicing removes the ITSM (immunoreceptor tyrosine-based switch motif) motif of SLAM family member 7 (SLAMF7), abrogating binding to SH2 domain-containing protein 1A (SH2D1A). The full-length isoform (Isoform CS1-L of SLAM family member 7 (SLAMF7)) has 2 ITSM motifs and only one is missing in the shorter splice variant (Isoform 19A24 of SLAM family member 7 (SLAMF7)). However, experiments showed only Isoform CS1-L of SLAM family member 7 (SLAMF7) binds to SH2D1A.
details

Signaling lymphocytic activation molecule - SLAMF1 -  Homo sapiens
LIG_SH2_IB276286BinaryPhysicochemical compatibilityPhosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein.
details
           
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