switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF00134 (9 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Cell cycle

Mitotic G1-G1/S phases

S Phase

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Cell cycle (KEGG - hsa04110)
DOC_CYCLIN_1	CDN1B_HUMAN	30	33	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated
DOC_CYCLIN_1	CDC6_HUMAN	94	98	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated
DOC_CYCLIN_1	CDN1A_HUMAN	19	22	Specificity	Competition	Cyclin-dependent kinase inhibitor 1 (CDKN1A) (p21) and the M-phase inducer phosphatase 1 (CDC25A) bind the same site on Cyclin proteins (e.g. G1/S-specific cyclin-E1 (CCNE1)), making their interactions mutually exclusive.	details	Curated
DOC_CYCLIN_1	MPIP1_HUMAN	11	15	Specificity	Competition	Cyclin-dependent kinase inhibitor 1 (CDKN1A) (p21) and the M-phase inducer phosphatase 1 (CDC25A) bind the same site on Cyclin proteins (e.g. G1/S-specific cyclin-E1 (CCNE1)), making their interactions mutually exclusive.	details	Curated
DOC_CYCLIN_1	RB_HUMAN	873	877	Specificity	Competition	The docking sites for PP1 (e.g. Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)) and Cdk-Cyclins (e.g. Cyclin-A2 (CCNA2)) on Retinoblastoma-associated protein (RB1) overlap, which makes their binding to RB1 mutually exclusive. Hypophosphorylated RB1 blocks E2F-dependent transcription, while hyperphosphorylation inactivates RB1 as a repressor, thereby promoting cell cycle progression.	details	Inferred
Mitotic G1-G1/S phases (Reactome - 453279)
DOC_CYCLIN_1	CDN1A_HUMAN	19	22	Specificity	Competition	Cyclin-dependent kinase inhibitor 1 (CDKN1A) (p21) and the M-phase inducer phosphatase 1 (CDC25A) bind the same site on Cyclin proteins (e.g. G1/S-specific cyclin-E1 (CCNE1)), making their interactions mutually exclusive.	details	Curated
DOC_CYCLIN_1	MPIP1_HUMAN	11	15	Specificity	Competition	Cyclin-dependent kinase inhibitor 1 (CDKN1A) (p21) and the M-phase inducer phosphatase 1 (CDC25A) bind the same site on Cyclin proteins (e.g. G1/S-specific cyclin-E1 (CCNE1)), making their interactions mutually exclusive.	details	Curated
S Phase (Reactome - 69242)
DOC_CYCLIN_1	CDN1B_HUMAN	30	33	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated
DOC_CYCLIN_1	CDC6_HUMAN	94	98	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated