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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P27986 (13 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
Aldosterone-regulated sodium reabsorptionEndocytosisErbB signaling pathway
Focal adhesionHIF-1 signaling pathwayInsulin signaling pathway
PI3K-Akt signaling pathwayRegulation of actin cytoskeleton


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Aldosterone-regulated sodium reabsorption (KEGG - hsa04960)
LIG_SH2_STAT5 INSR_HUMAN13611364SpecificityDomain hidingPIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.
details
Inferred

Endocytosis (KEGG - hsa04144)
LIG_SH2_STAT5 ERBB4_HUMAN10561059SpecificityAltered binding specificityPhosphorylation-dependent binding of Receptor tyrosine-protein kinase erbB-4 (ERBB4) to the SH2 domains of Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) results in signaling activation, while binding to the WW domains of E3 ubiquitin-protein ligase Itchy homolog (ITCH) to unphopshorylated ERBB4 results in ubiquitylation, endocytosis and ultimately degradation of ERBB4.
details
Inferred

ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_STAT5 ERBB4_HUMAN10561059SpecificityAltered binding specificityPhosphorylation-dependent binding of Receptor tyrosine-protein kinase erbB-4 (ERBB4) to the SH2 domains of Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) results in signaling activation, while binding to the WW domains of E3 ubiquitin-protein ligase Itchy homolog (ITCH) to unphopshorylated ERBB4 results in ubiquitylation, endocytosis and ultimately degradation of ERBB4.
details
Inferred
LIG_SH2_IIA ERBB4_HUMAN10561059BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Receptor tyrosine-protein kinase erbB-4 (ERBB4), abrogating binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1). The SH2-binding motif overlaps with a WW-binding motif. Binding of these motifs is regulated in a phosphorylation-dependent manner, ensuring ERBB4 is either endocytosed or stabilised.
details
Inferred
LIG_SH2_IIA ERBB4_HUMAN10561059BinaryPre‑translationalAlternative splicing removes the SH2-binding motif of Receptor tyrosine-protein kinase erbB-4 (ERBB4), abrogating binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1). The SH2-binding motif overlaps with a WW-binding motif. Binding of these motifs is regulated in a phosphorylation-dependent manner, ensuring ERBB4 is either endocytosed or stabilised.
details
Inferred
LIG_SH2_STAT5 GAB1_HUMAN472475BinaryPhysicochemical compatibilityPhosphorylation of Y472 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).
details
Curated
LIG_SH2_STAT5 GAB1_HUMAN447450BinaryPhysicochemical compatibilityPhosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).
details
Curated

Focal adhesion (KEGG - hsa04510)
LIG_SH2_IIA PGFRB_HUMAN751755BinaryPhysicochemical compatibilityPhosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.
details
Inferred

HIF-1 signaling pathway (KEGG - hsa04066)
LIG_SH2_STAT5 INSR_HUMAN13611364SpecificityDomain hidingPIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.
details
Inferred

Insulin signaling pathway (KEGG - hsa04910)
LIG_SH2_STAT5 INSR_HUMAN13611364SpecificityDomain hidingPIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.
details
Inferred

PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_STAT5 INSR_HUMAN13611364SpecificityDomain hidingPIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.
details
Inferred
LIG_SH2_IIA PGFRB_HUMAN751755BinaryPhysicochemical compatibilityPhosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.
details
Inferred

Regulation of actin cytoskeleton (KEGG - hsa04810)
LIG_SH2_IIA PGFRB_HUMAN751755BinaryPhysicochemical compatibilityPhosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.
details
Inferred
           
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