switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P30305 (3 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Motif

Protein

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Information

Evidence

Cell cycle (KEGG - hsa04110)
LIG_PLK	MPIP2_HUMAN	49	51	Binary	Physicochemical compatibility	Phosphorylation of S50 in the PLK-docking motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates and activates M-phase inducer phosphatase 2 (CDC25B).	details	Curated
LIG_14-3-3_3	MPIP2_HUMAN	320	325	Binary	Physicochemical compatibility	Phosphorylation of S321 in the 14-3-3-binding motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1) during mitosis abolishes binding of the motif, phosphorylated at S323, to 14-3-3 protein beta/alpha (YWHAB), thereby maintaining active Cdc25B.	details	Curated
DEG_APCC_KENBOX_2	MPIP2_HUMAN	191	195	Binary	Pre‑translational	Alternative splicing removes the APC/C KEN-box degron motif of M-phase inducer phosphatase 2 (CDC25B), abrogating binding to Fizzy-related protein homolog (FZR1). The motif-lacking Isoform CDC25B2 of M-phase inducer phosphatase 2 (CDC25B) is not degraded during mitosis, unlike other isoforms.	details	Curated