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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P30305 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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M-phase inducer phosphatase 2


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

M-phase inducer phosphatase 2 - CDC25B -  Homo sapiens
LIG_PLK4951BinaryPhysicochemical compatibilityPhosphorylation of S50 in the PLK-docking motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates and activates M-phase inducer phosphatase 2 (CDC25B).
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LIG_14-3-3_3320325BinaryPhysicochemical compatibilityPhosphorylation of S321 in the 14-3-3-binding motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1) during mitosis abolishes binding of the motif, phosphorylated at S323, to 14-3-3 protein beta/alpha (YWHAB), thereby maintaining active Cdc25B.
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DEG_APCC_KENBOX_2191195BinaryPre‑translationalAlternative splicing removes the APC/C KEN-box degron motif of M-phase inducer phosphatase 2 (CDC25B), abrogating binding to Fizzy-related protein homolog (FZR1). The motif-lacking Isoform CDC25B2 of M-phase inducer phosphatase 2 (CDC25B) is not degraded during mitosis, unlike other isoforms.
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