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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Apoptosis (KEGG - hsa04210) | ||||||||
| CLV_C14_caspase-8-10 | CASP3_HUMAN | 172 | 175 | Binary | Physicochemical compatibility | Phosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3). | Curated | |
Apoptotic execution phase (Reactome - 75153) | ||||||||
| CLV_C14_caspase-8-10 | CASP3_HUMAN | 172 | 175 | Binary | Physicochemical compatibility | Phosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3). | Curated | |
| CLV_C14_Caspase3-7 | KPCD_HUMAN | 326 | 330 | Binary | Pre‑translational | Alternative splicing inserts exons within the Caspase-3 scission motif of Protein kinase C delta type (PRKCD), abrogating binding to Caspase-3 (CASP3). Cleavage of PKCdeltaI Protein kinase C delta type (PRKCD) by caspase-3 releases a catalytically active C-terminal fragment that is sufficient to induce apoptosis. This inserted exon disrupts scission motifs and therefore the PKCdeltaVIII (GENBANK:DQ516383) splice variant functions as an anti-apoptotic protein in NT2 cells. | Curated | |
p53 signaling pathway (KEGG - hsa04115) | ||||||||
| CLV_C14_Caspase3-7 | PTEN_HUMAN | 381 | 385 | Binary | Physicochemical compatibility | Phosphorylation of S385 adjacent to the cleavage motif of Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) by CK2 subfamily prevents cleavage by Caspase-3 (CASP3). | Inferred | |