switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q05397 (8 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Axon guidance	Chemokine signaling pathway	ErbB signaling pathway
Focal adhesion	Leukocyte transendothelial migration	Regulation of actin cytoskeleton
VEGF signaling pathway

Motif

Protein

Start

End

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Information

Evidence

Axon guidance (KEGG - hsa04360)
LIG_SH2_IA	FAK1_HUMAN	389	405	Binary	Physicochemical compatibility	Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.	details	Inferred
Chemokine signaling pathway (KEGG - hsa04062)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_IA	FAK1_HUMAN	389	405	Binary	Physicochemical compatibility	Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.	details	Inferred
LIG_SH2_SRC	FAK1_HUMAN	397	400	Binary	Physicochemical compatibility	Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to Neuronal proto-oncogene tyrosine-protein kinase Src (Src).	details	Curated
Focal adhesion (KEGG - hsa04510)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
Leukocyte transendothelial migration (KEGG - hsa04670)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
Regulation of actin cytoskeleton (KEGG - hsa04810)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred
VEGF signaling pathway (KEGG - hsa04370)
LIG_FAT_LD_1	PAXI_HUMAN	4	12	Binary	Pre‑translational	Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).	details	Inferred