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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P09619 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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Platelet-derived growth factor receptor beta


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Platelet-derived growth factor receptor beta - PDGFRB -  Homo sapiens
LIG_SH2_IIA751755BinaryPhysicochemical compatibilityPhosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.
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LIG_SH2_IIA10181029BinaryPhysicochemical compatibilityPhosphorylation of Y1021 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.
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LIG_PDZ_Class_111011106BinaryPhysicochemical compatibilityPhosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.
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