switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: ELM:LIG_SH3_2 (2 hits) x

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Curated inferred

x Index

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Protein

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Information

Evidence

GSK-3 subfamily
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Curated
RAC subfamily
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Curated