About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:LIG_SH3_2 (6 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Disintegrin and metalloproteinase domain-containing protein 15Dynamin-2Myc proto-oncogene protein
Serine/threonine-protein kinase PAK 1Synaptojanin-2 (Rattus)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Disintegrin and metalloproteinase domain-containing protein 15 - ADAM15 -  Homo sapiens
LIG_SH3_2767772BinaryPre‑translationalAlternative splicing removes the SH3-binding motif of Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), abrogating binding to Proto-oncogene tyrosine-protein kinase Src (SRC). The overexpression of this splice variant has been linked to clinical aggressiveness of breast cancer.
details

Dynamin-2 - DNM2 -  Homo sapiens
LIG_SH3_2829834SpecificityDomain hidingAn intramolecular interaction of a Bin1 SH3 binding motif, encoded by exon 10, with the Dynamin-2 (DNM2) SH3 domain prevents binding of dynamin2 to the Bin1 SH3 domain. Binding of PI(4,5)P2 to the overlapping PI(4,5)P2 binding motif encoded by exon 10 relieves the intramolecular auto-inhibitory interaction and allows the Bin1 SH3 domain to interact with the dynamin2 PxxP motif
details

Myc proto-oncogene protein - MYC -  Homo sapiens
LIG_SH3_26065BinaryPhysicochemical compatibilityPhosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).
details
LIG_SH3_26065SpecificityDomain hidingAn intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Myc proto-oncogene protein (MYC).
details

Serine/threonine-protein kinase PAK 1 - PAK1 -  Homo sapiens
LIG_SH3_21318BinaryPhysicochemical compatibilityPhosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.
details

Synaptojanin-2 - Synj2 -  Rattus norvegicus
LIG_SH3_211201125BinaryPre‑translationalAlternative splicing removes the SH3-binding motif of Synaptojanin-2 (Synj2), abrogating binding to Endophilin-A2 (Sh3gl1). Endophilin-A1 (Sh3gl2) and Endophilin-A3 (Sh3gl3) were also shown to bind in this study.
details
           
Please send any suggestions/comments to: switches@elm.eu.org