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UNIPROT:O95644 (4 hits)
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Index
Glycogen synthase kinase-3 beta
cAMP subfamily
()
Motif
Protein
Start
End
Switch Type
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Information
Evidence
cAMP subfamily
MOD_GSK3_1
NFAC1_HUMAN
287
294
Binary
Physicochemical compatibility
Phosphorylation of S294 adjacent to the NLS of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
by
cAMP subfamily
primes
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
for subsequent phosphorylation by
Glycogen synthase kinase-3 beta (GSK3B)
, which results in inhibition of nuclear import of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
.
details
Curated
MOD_GSK3_1
NFAC1_HUMAN
238
245
Binary
Physicochemical compatibility
Phosphorylation of S245 adjacent to the NLS of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
by
cAMP subfamily
primes
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
for subsequent phosphorylation by
Glycogen synthase kinase-3 beta (GSK3B)
, which results in inhibition of nuclear import of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
.
details
Curated
Glycogen synthase kinase-3 beta -
GSK3B
-  
Homo sapiens
TRG_NLS_MonoExtN_4
NFAC1_HUMAN
262
269
Binary
Physicochemical compatibility
Phosphorylation of S241 and S290 adjacent to the NLS of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
by
Glycogen synthase kinase-3 beta (GSK3B)
and
Glycogen synthase kinase-3 beta (GSK3B)
inhibits nuclear import of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
by disrupting its interaction with
Importin subunit alpha-2 (KPNA2)
. Calcium-dependent dephosphorylation by calcineurin promotes nuclear import.
details
Curated
TRG_NLS_MonoExtN_4
NFAC1_HUMAN
262
269
Binary
Physicochemical compatibility
Phosphorylation of S241 and S290 adjacent to the NLS of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
by
Glycogen synthase kinase-3 beta (GSK3B)
and
Glycogen synthase kinase-3 beta (GSK3B)
inhibits nuclear import of
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
by disrupting its interaction with
Importin subunit alpha-2 (KPNA2)
. Calcium-dependent dephosphorylation by calcineurin promotes nuclear import.
details
Curated