switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF00533 (4 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Cyclin-dependent kinase 2	DNA-dependent protein kinase catalytic subunit	Serine-protein kinase ATM
Serine/threonine-protein kinase 4

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Cyclin-dependent kinase 2 - CDK2 - Homo sapiens
LIG_BRCT_BRCA1_1	ATRIP_HUMAN	238	242	Binary	Physicochemical compatibility	Phosphorylation of S239 in the BRCT-binding motif of ATR-interacting protein (ATRIP) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.	details	Inferred
DNA-dependent protein kinase catalytic subunit - PRKDC - Homo sapiens
LIG_BRCT_MDC1_1	H2AX_HUMAN	139	143	Binary	Physicochemical compatibility	Phosphorylation of S140 in the BRCT-binding motif of Histone H2A.x (H2AFX) induces binding to the Mediator of DNA damage checkpoint protein 1 (MDC1) protein.	details	Curated
Serine-protein kinase ATM - ATM - Homo sapiens
LIG_BRCT_MDC1_1	H2AX_HUMAN	139	143	Binary	Physicochemical compatibility	Phosphorylation of S140 in the BRCT-binding motif of Histone H2A.x (H2AFX) induces binding to the Mediator of DNA damage checkpoint protein 1 (MDC1) protein.	details	Curated
Serine/threonine-protein kinase 4 - STK4 - Homo sapiens
LIG_BRCT_MDC1_1	H2AX_HUMAN	139	143	Binary	Physicochemical compatibility	Phosphorylation of S140 in the BRCT-binding motif of Histone H2A.x (H2AFX) induces binding to the Mediator of DNA damage checkpoint protein 1 (MDC1) protein.	details	Inferred