switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P05067 (7 hits) x

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Curated inferred

x Index

Cyclin-dependent kinase 1

Glycogen synthase kinase-3 beta

Tyrosine-protein kinase Fyn

Motif

Protein

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Evidence

Cyclin-dependent kinase 1 - CDK1 - Homo sapiens
LIG_PTB_Apo_2	A4_HUMAN	756	763	Binary	Physicochemical compatibility	Phosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).	details	Inferred
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
Glycogen synthase kinase-3 beta - GSK3B - Homo sapiens
LIG_PTB_Apo_2	A4_HUMAN	756	763	Binary	Physicochemical compatibility	Phosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).	details	Inferred
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_SH2_GRB2	A4_HUMAN	757	760	Cumulative	Rheostatic	While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.	details	Inferred
LIG_PTB_Apo_2	A4_HUMAN	756	763	Specificity	Altered binding specificity	Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).	details	Inferred
LIG_SH2_GRB2	A4_HUMAN	757	760	Specificity	Altered binding specificity	Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).	details	Inferred