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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:DEG_SCF_FBW7_2 (2 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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DEG_SCF_FBW7_2


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

DEG_SCF_FBW7_2 - The TPxxE phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex.
LT_SV40699705BinaryPhysicochemical compatibilityPhosphorylation of T701 in the degron of Large T antigen induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.
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NOTC1_HUMAN25082515BinaryPhysicochemical compatibilityPhosphorylation of T2511 in the degron of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.
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