switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: UNIPROT:P00533 (7 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Calcium signaling pathway	ErbB signaling pathway	MAPK signaling pathway
PI3K-Akt signaling pathway

Motif

Protein

Start

End

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Switch description

Information

Evidence

Calcium signaling pathway (KEGG - hsa04020)
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1).	details	Curated
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1).	details	Curated
LIG_SH2_SRC	EGFR_HUMAN	1125	1128	Binary	Physicochemical compatibility	Phosphorylation of Y1125 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Adapter molecule crk (CRK).	details	Curated
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Cytoplasmic protein NCK1 (NCK1).	details	Curated
MAPK signaling pathway (KEGG - hsa04010)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated
PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_IC	EGFR_HUMAN	1092	1100	Binary	Physicochemical compatibility	Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Curated