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UNIPROT:P06493 (4 hits)
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Index
Cell cycle
Centrosome maturation
Motif
Protein
Start
End
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Information
Evidence
Cell cycle
(
KEGG - hsa04110
)
LIG_PLK
MPIP3_HUMAN
129
131
Binary
Physicochemical compatibility
Phosphorylation of T130 in the PLK-docking motif of
M-phase inducer phosphatase 3 (CDC25C)
by
Cyclin-dependent kinase 1 (CDK1)
-
Cyclin AB subfamily
generates a recruitment site for
Serine/threonine-protein kinase PLK1 (PLK1)
, which then phosphorylates
M-phase inducer phosphatase 3 (CDC25C)
. This results in inactivation of the NES of
M-phase inducer phosphatase 3 (CDC25C)
, thereby promoting its nuclear localization.
details
Curated
LIG_PLK
MPIP2_HUMAN
49
51
Binary
Physicochemical compatibility
Phosphorylation of S50 in the PLK-docking motif of
M-phase inducer phosphatase 2 (CDC25B)
by
Cyclin-dependent kinase 1 (CDK1)
-
Cyclin AB subfamily
generates a recruitment site for
Serine/threonine-protein kinase PLK1 (PLK1)
, which then phosphorylates and activates
M-phase inducer phosphatase 2 (CDC25B)
.
details
Curated
LIG_14-3-3_3
MPIP2_HUMAN
320
325
Binary
Physicochemical compatibility
Phosphorylation of S321 in the 14-3-3-binding motif of
M-phase inducer phosphatase 2 (CDC25B)
by
Cyclin-dependent kinase 1 (CDK1)
during mitosis abolishes binding of the motif, phosphorylated at S323, to
14-3-3 protein beta/alpha (YWHAB)
, thereby maintaining active Cdc25B.
details
Curated
Centrosome maturation
(
Reactome - 380287
)
MOD_CDK_1
ODFP2_HUMAN
793
799
Binary
Pre‑translational
Alternative splicing removes the cyclin-dependent kinase (CDK) phosphorylation motif of
Isoform Cenexin 1 of Outer dense fiber protein 2 (ODF2)
, abrogating binding to
Cyclin-dependent kinase 1 (CDK1)
. This phosphorylation is required for the recruitment of
Serine/threonine-protein kinase PLK1 (PLK1)
. The C-terminal extension of
Isoform Cenexin 1 of Outer dense fiber protein 2 (ODF2)
has the ability to distinctly localise to mother centriole whereas the splice variant (e.g.
Isoform Cenexin 1 of Outer dense fiber protein 2 (ODF2)
), which does not have this extension, permits
ODF2
to associate with sperm tail.
details
Curated