switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P16333 (5 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Axon guidance

ErbB signaling pathway

T cell receptor signaling pathway

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Axon guidance (KEGG - hsa04360)
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Inferred
LIG_SH2_IA	EPHA3_HUMAN	597	606	Binary	Physicochemical compatibility	Phosphorylation of Y602 in the SH2-binding motif of Ephrin type-A receptor 3 (EPHA3) induces binding to the Cytoplasmic protein NCK1 (NCK1) protein.	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Inferred
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to Cytoplasmic protein NCK1 (NCK1).	details	Curated
T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Inferred