switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: IPR:IPR000980 (6 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Jak-STAT signaling pathway	Osteoclast differentiation	PI3K-Akt signaling pathway
T cell receptor signaling pathway

Motif

Protein

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End

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Information

Evidence

Jak-STAT signaling pathway (KEGG - hsa04630)
LIG_SH2_IE	INAR1_HUMAN	458	474	Binary	Physicochemical compatibility	Phosphorylation of Y466 in the SH2-binding motif of Interferon alpha/beta receptor 1 (IFNAR1) induces binding to the Non-receptor tyrosine-protein kinase TYK2 (TYK2) protein.	details	Inferred
LIG_SH2_IE	INAR1_HUMAN	473	489	Binary	Physicochemical compatibility	Phosphorylation of Y481 in the SH2-binding motif of Interferon alpha/beta receptor 1 (IFNAR1) induces binding to the Non-receptor tyrosine-protein kinase TYK2 (TYK2) protein.	details	Inferred
Osteoclast differentiation (KEGG - hsa04380)
LIG_SH2_IE	INAR1_HUMAN	458	474	Binary	Physicochemical compatibility	Phosphorylation of Y466 in the SH2-binding motif of Interferon alpha/beta receptor 1 (IFNAR1) induces binding to the Non-receptor tyrosine-protein kinase TYK2 (TYK2) protein.	details	Inferred
LIG_SH2_IE	INAR1_HUMAN	473	489	Binary	Physicochemical compatibility	Phosphorylation of Y481 in the SH2-binding motif of Interferon alpha/beta receptor 1 (IFNAR1) induces binding to the Non-receptor tyrosine-protein kinase TYK2 (TYK2) protein.	details	Inferred
PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred
T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH2_IIC	ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details	Inferred