About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF00656 (4 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
ApoptosisApoptotic execution phasep53 signaling pathway


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Apoptosis (KEGG - hsa04210)
CLV_C14_caspase-8-10 CASP3_HUMAN172175BinaryPhysicochemical compatibilityPhosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3).
details
Curated

Apoptotic execution phase (Reactome - 75153)
CLV_C14_caspase-8-10 CASP3_HUMAN172175BinaryPhysicochemical compatibilityPhosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3).
details
Curated
CLV_C14_Caspase3-7 KPCD_HUMAN326330BinaryPre‑translationalAlternative splicing inserts exons within the Caspase-3 scission motif of Protein kinase C delta type (PRKCD), abrogating binding to Caspase-3 (CASP3). Cleavage of PKCdeltaI Protein kinase C delta type (PRKCD) by caspase-3 releases a catalytically active C-terminal fragment that is sufficient to induce apoptosis. This inserted exon disrupts scission motifs and therefore the PKCdeltaVIII (GENBANK:DQ516383) splice variant functions as an anti-apoptotic protein in NT2 cells.
details
Curated

p53 signaling pathway (KEGG - hsa04115)
CLV_C14_Caspase3-7 PTEN_HUMAN381385BinaryPhysicochemical compatibilityPhosphorylation of S385 adjacent to the cleavage motif of Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) by CK2 subfamily prevents cleavage by Caspase-3 (CASP3).
details
Inferred
           
Please send any suggestions/comments to: switches@elm.eu.org