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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P26039 (3 hits) x


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Focal adhesion


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Focal adhesion (KEGG - mmu04510)
LIG_PTB_Talin PI51C_MOUSE645648BinaryPre‑translationalAlternative splicing removes the PTB domain-binding motif of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c), abrogating binding to Talin-1 (Tln1). Integrin receptors, Tln1 and Isoform PIPKIgamma661 of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) (PIPKIgamma661) are recruited to focal adhesions, inducing synthesis of PI(4,5)P2. The regulated and localised generation of PI(4,5)P2 facilitates the assembly and/or disassembly of focal adhesions.
details
Inferred
LIG_PTB_Talin PI51C_MOUSE645648BinaryPhysicochemical compatibilityPhosphorylation of S645 in the PTB-binding motif of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with Talin-1 (Tln1).
details
Inferred
LIG_PTB_Talin PI51C_MOUSE645648BinaryPhysicochemical compatibilityPhosphorylation of Y644 in Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) promotes its association with Talin-1 (Tln1).
details
Inferred
           
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