About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:TRG_NES_CRM1_1 (4 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Catenin delta-1Cellular tumor antigen p53M-phase inducer phosphatase 3
Protein PML


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Catenin delta-1 - CTNND1 -  Homo sapiens
TRG_NES_CRM1_1942956BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Catenin delta-1 (CTNND1), abrogating binding to Exportin-1 (XPO1). Despite demonstration of the importance of the NES for removing Catenin delta-1 (CTNND1) from the nucleus, those isoforms without NES are rarely found in the nucleus.
details

Cellular tumor antigen p53 - TP53 -  Homo sapiens
TRG_NES_CRM1_1339352BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Cellular tumor antigen p53 (TP53), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.
details

M-phase inducer phosphatase 3 - CDC25C -  Homo sapiens
TRG_NES_CRM1_1189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details

Protein PML - PML -  Homo sapiens
TRG_NES_CRM1_1702716BinaryPre‑translationalAlternative splicing removes the nuclear export signal (NES) of Protein PML (PML), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.
details
           
Please send any suggestions/comments to: switches@elm.eu.org