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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Epidermal growth factor receptor | Receptor tyrosine-protein kinase erbB-2 | Receptor tyrosine-protein kinase erbB-3 |
| Tyrosine-protein kinase JAK2 |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Epidermal growth factor receptor - EGFR - Homo sapiens | |||||||
| LIG_SH2_IE | 1008 | 1024 | Binary | Physicochemical compatibility | Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein. | ||
Receptor tyrosine-protein kinase erbB-2 - ERBB2 - Homo sapiens | |||||||
| LIG_SH2_IE | 1015 | 1031 | Binary | Physicochemical compatibility | Phosphorylation of Y1023 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein. | ||
Receptor tyrosine-protein kinase erbB-3 - ERBB3 - Homo sapiens | |||||||
| LIG_SH2_IE | 1320 | 1336 | Binary | Physicochemical compatibility | Phosphorylation of Y1328 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein. | ||
| LIG_SH2_IE | 1268 | 1284 | Binary | Physicochemical compatibility | Phosphorylation of Y1276 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the Tyrosine-protein kinase JAK2 (JAK2) protein. | ||
Tyrosine-protein kinase JAK2 - JAK2 - Homo sapiens | |||||||
| LIG_SH2_IIB | 804 | 823 | Binary | Physicochemical compatibility | Phosphorylation of Y813 in the SH2-binding motif of Tyrosine-protein kinase JAK2 (JAK2) induces binding to the SH2B adapter protein 1 (SH2B1) protein. | ||