switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q16665 (3 hits) x

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Curated inferred

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Motif

Protein

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Information

Evidence

Egl nine homolog 1 - EGLN1 - Homo sapiens
DEG_ODPH_VHL_1	HIF1A_HUMAN	400	413	Binary	Physicochemical compatibility	Hydroxylation of P402 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
DEG_ODPH_VHL_1	HIF1A_HUMAN	562	574	Binary	Physicochemical compatibility	Hydroxylation of P564 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
Hypoxia-inducible factor 1-alpha inhibitor - HIF1AN - Homo sapiens
LIG_TAZ1	HIF1A_HUMAN	792	795	Binary	Physicochemical compatibility	Under normoxic conditions interaction of Hypoxia-inducible factor 1-alpha (HIF1A) with transcriptional coactivators such as CREB-binding protein (Crebbp) is inhibited by hydroxylation of N803.	details	Curated