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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:Q16665 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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DEG_ODPH_VHL_1LIG_TAZ1


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

DEG_ODPH_VHL_1 - Oxygen dependent prolyl hydroxylation motif in the unstructured region of hypoxia-inducible factor protein and bound by the VHL ligand.
HIF1A_HUMAN400413BinaryPhysicochemical compatibilityHydroxylation of P402 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.
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HIF1A_HUMAN562574BinaryPhysicochemical compatibilityHydroxylation of P564 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.
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LIG_TAZ1 -
HIF1A_HUMAN792795BinaryPhysicochemical compatibilityUnder normoxic conditions interaction of Hypoxia-inducible factor 1-alpha (HIF1A) with transcriptional coactivators such as CREB-binding protein (Crebbp) is inhibited by hydroxylation of N803.
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