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Filtered:
UNIPROT:Q16665 (6 hits)
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inferred
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Index
HIF-1 signaling pathway
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
HIF-1 signaling pathway
(
KEGG - hsa04066
)
DEG_ODPH_VHL_1
HIF1A_HUMAN
400
413
Binary
Physicochemical compatibility
Hydroxylation of P402 in the VHL-binding motif of
Hypoxia-inducible factor 1-alpha (HIF1A)
induces binding to the
Von Hippel-Lindau disease tumor suppressor (VHL)
protein.
details
Curated
DEG_ODPH_VHL_1
HIF1A_HUMAN
562
574
Binary
Physicochemical compatibility
Hydroxylation of P564 in the VHL-binding motif of
Hypoxia-inducible factor 1-alpha (HIF1A)
induces binding to the
Von Hippel-Lindau disease tumor suppressor (VHL)
protein.
details
Curated
LIG_TAZ1
HIF1A_HUMAN
792
795
Binary
Physicochemical compatibility
Under normoxic conditions interaction of
Hypoxia-inducible factor 1-alpha (HIF1A)
with transcriptional coactivators such as
CREB-binding protein (Crebbp)
is inhibited by hydroxylation of N803.
details
Curated
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
(
Reactome - 1234174
)
DEG_ODPH_VHL_1
HIF1A_HUMAN
400
413
Binary
Physicochemical compatibility
Hydroxylation of P402 in the VHL-binding motif of
Hypoxia-inducible factor 1-alpha (HIF1A)
induces binding to the
Von Hippel-Lindau disease tumor suppressor (VHL)
protein.
details
Curated
DEG_ODPH_VHL_1
HIF1A_HUMAN
562
574
Binary
Physicochemical compatibility
Hydroxylation of P564 in the VHL-binding motif of
Hypoxia-inducible factor 1-alpha (HIF1A)
induces binding to the
Von Hippel-Lindau disease tumor suppressor (VHL)
protein.
details
Curated
LIG_TAZ1
HIF1A_HUMAN
792
795
Binary
Physicochemical compatibility
Under normoxic conditions interaction of
Hypoxia-inducible factor 1-alpha (HIF1A)
with transcriptional coactivators such as
CREB-binding protein (Crebbp)
is inhibited by hydroxylation of N803.
details
Curated
