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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF00498 (12 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
DNA repair protein RAD9 (Saccharomyces)DNA repair protein XRCC1MKI67 FHA domain-interacting nucleolar phosphoprotein
Mediator of replication checkpoint protein 1 (Schizosaccharomyces)RNA-binding protein PIN4 (Saccharomyces)Receptor protein kinase CLAVATA1 (Arabidopsis)
Serine/threonine-protein kinase Chk2Uncharacterized protein Rv1827/MT1875 (Mycobacterium)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

DNA repair protein RAD9 - RAD9 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
LIG_FHA_1601607BinaryPhysicochemical compatibilityPhosphorylation of T603 in the FHA-binding motif of DNA repair protein RAD9 (RAD9) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.
details
LIG_FHA_2153159BinaryPhysicochemical compatibilityPhosphorylation of T155 in the FHA-binding motif of DNA repair protein RAD9 (RAD9) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.
details
LIG_FHA_2190196BinaryPhysicochemical compatibilityPhosphorylation of T192 in the FHA-binding motif of DNA repair protein RAD9 (RAD9) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.
details

DNA repair protein XRCC1 - XRCC1 -  Homo sapiens
LIG_FHA_2521527BinaryPhysicochemical compatibilityPhosphorylation of T523 in the FHA-binding motif of DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Aprataxin (APTX) protein.
details

MKI67 FHA domain-interacting nucleolar phosphoprotein - MKI67IP -  Homo sapiens
LIG_FHA_2238244SpecificityAltered binding specificityPhosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67).
details
LIG_FHA_2238244CumulativeRheostaticPhosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details
details

Mediator of replication checkpoint protein 1 - mrc1 -  Schizosaccharomyces pombe (strain 972 / ATCC 24843)
LIG_FHA_2643649BinaryPhysicochemical compatibilityPhosphorylation of T645 in the FHA-binding motif of Mediator of replication checkpoint protein 1 (mrc1) induces binding to the Serine/threonine-protein kinase cds1 (cds1) protein.
details

RNA-binding protein PIN4 - PIN4 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
LIG_FHA_1303309BinaryPhysicochemical compatibilityPhosphorylation of T305 in the FHA-binding motif of RNA-binding protein PIN4 (PIN4) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.
details

Receptor protein kinase CLAVATA1 - CLV1 -  Arabidopsis thaliana
LIG_FHA_1866872BinaryPhysicochemical compatibilityPhosphorylation of T868 in the FHA-binding motif of Receptor protein kinase CLAVATA1 (CLV1) induces binding to the Protein phosphatase 2C 70 (KAPP) protein.
details

Serine/threonine-protein kinase Chk2 - CHEK2 -  Homo sapiens
LIG_FHA_16672BinaryPhysicochemical compatibilityPhosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.
details

Uncharacterized protein Rv1827/MT1875 - Rv1827 -  Mycobacterium tuberculosis
LIG_FHA_11925BinaryPhysicochemical compatibilityPhosphorylation of T21 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Probable serine/threonine-protein kinase pknG (pknG) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details).
details
LIG_FHA_12026BinaryPhysicochemical compatibilityPhosphorylation of T22 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Serine/threonine-protein kinase pknB (pknB) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details).
details
           
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