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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF00656 (4 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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Carcinoembryonic antigen-related cell adhesion molecule 1 (Mus)Caspase-3Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Protein kinase C delta type


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Carcinoembryonic antigen-related cell adhesion molecule 1 - Ceacam1 -  Mus musculus
CLV_CASPASE3_1457460BinaryPre‑translationalAlternative splicing removes the caspase-3 scission site of Carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1), preventing cleavage by Caspase-3 (Casp3). The presence of cleavage sites allows production of a stronger adhession molecule.
details

Caspase-3 - CASP3 -  Homo sapiens
CLV_C14_caspase-8-10172175BinaryPhysicochemical compatibilityPhosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3).
details

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN - PTEN -  Homo sapiens
CLV_C14_Caspase3-7381385BinaryPhysicochemical compatibilityPhosphorylation of S385 adjacent to the cleavage motif of Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) by CK2 subfamily prevents cleavage by Caspase-3 (CASP3).
details

Protein kinase C delta type - PRKCD -  Homo sapiens
CLV_C14_Caspase3-7326330BinaryPre‑translationalAlternative splicing inserts exons within the Caspase-3 scission motif of Protein kinase C delta type (PRKCD), abrogating binding to Caspase-3 (CASP3). Cleavage of PKCdeltaI Protein kinase C delta type (PRKCD) by caspase-3 releases a catalytically active C-terminal fragment that is sufficient to induce apoptosis. This inserted exon disrupts scission motifs and therefore the PKCdeltaVIII (GENBANK:DQ516383) splice variant functions as an anti-apoptotic protein in NT2 cells.
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