Nuclear factor of activated T-cells, cytoplasmic 1 - NFATC1 - Homo sapiens
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| MOD_GSK3_1 | 287 | 294 | Binary | Physicochemical compatibility | Phosphorylation of S294 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1). | details |
| MOD_GSK3_1 | 238 | 245 | Binary | Physicochemical compatibility | Phosphorylation of S245 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1). | details |
| TRG_NLS_MonoExtN_4 | 262 | 269 | Binary | Physicochemical compatibility | Phosphorylation of S241 and S290 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by Glycogen synthase kinase-3 beta (GSK3B) and Glycogen synthase kinase-3 beta (GSK3B) inhibits nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by disrupting its interaction with Importin subunit alpha-2 (KPNA2). Calcium-dependent dephosphorylation by calcineurin promotes nuclear import. | details |
| MOD_SUMO | 701 | 704 | Binary | Pre‑translational | Alternative splicing removes the Sumoylation motif (SIM) of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), preventing the sumolyation of Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1). Both the Isoform C-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) and Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) exert a differential effect upon IL-2 expression. However, the longer isoform, Isoform C-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), has a sumoylation motif and is therefore negatively regulated in a sumolyation-dependent manner. | details |
| MOD_SUMO | 913 | 916 | Binary | Pre‑translational | Alternative splicing removes the Sumoylation motif (SIM) of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), preventing the sumolyation of Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1). Both the Isoform C-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) and Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) exert a differential effect upon IL-2 expression. However, the longer isoform, Isoform C-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), has a sumoylation motif and is therefore negatively regulated in a sumolyation-dependent manner. | details |
