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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P22681 (5 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
E3 ubiquitin-protein ligase CBLEpidermal growth factor receptorProtein sprouty homolog 2


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

E3 ubiquitin-protein ligase CBL - CBL -  Homo sapiens
LIG_SH2_IB770780BinaryPhysicochemical compatibilityPhosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.
details

Epidermal growth factor receptor - EGFR -  Homo sapiens
LIG_TKB10691074BinaryPhysicochemical compatibilityPhosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
details
LIG_TKB10691074CumulativeRheostaticWhile phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details

Protein sprouty homolog 2 - SPRY2 -  Homo sapiens
LIG_TKB5560BinaryPhysicochemical compatibilityPhosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
details
LIG_TKB5560CumulativeRheostaticWhile phosphorylation of Y55 induces binding, additional phosphorylation of T56 in the TKB-binding motif of Protein sprouty homolog 2 (SPRY2) lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
           
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