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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P43405 (8 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
High affinity immunoglobulin epsilon receptor subunit gammaLow affinity immunoglobulin gamma Fc region receptor II-aT-cell surface glycoprotein CD3 epsilon chain
Tyrosine-protein kinase SYK


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

High affinity immunoglobulin epsilon receptor subunit gamma - FCER1G -  Homo sapiens
LIG_TYR_ITAM6279Avidity‑sensingPhosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
details
LIG_TYR_ITAM6279Avidity‑sensingPhosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
details
LIG_SH2_IA7579BinaryPhysicochemical compatibilityPhosphorylation of Y76 in the SH2-binding motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces binding to the Tyrosine-protein kinase SYK (SYK) protein.
details

Low affinity immunoglobulin gamma Fc region receptor II-a - FCGR2A -  Homo sapiens
LIG_TYR_ITAM285307Avidity‑sensingPhosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
details
LIG_TYR_ITAM285307Avidity‑sensingPhosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
details

T-cell surface glycoprotein CD3 epsilon chain - CD3E -  Homo sapiens
LIG_TYR_ITAM185202Avidity‑sensingPhosphorylation of Y188 and Y199 in the ITAM motif of T-cell surface glycoprotein CD3 epsilon chain (CD3E) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
details
LIG_TYR_ITAM185202Avidity‑sensingPhosphorylation of Y188 and Y199 in the ITAM motif of T-cell surface glycoprotein CD3 epsilon chain (CD3E) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
details

Tyrosine-protein kinase SYK - SYK -  Homo sapiens
LIG_SH2_IIC315331BinaryPhysicochemical compatibilityPhosphorylation of Y323 in the SH2-binding motif of Tyrosine-protein kinase SYK (SYK) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.
details
           
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