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| Protein kinase C beta type | Ribosomal protein S6 kinase alpha-3 (Mus) | Serine/threonine-protein kinase TOR1 (Saccharomyces) |
| Serine/threonine-protein kinase mTOR |
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Protein kinase C beta type - PRKCB - Homo sapiens | ||||||||
| DOC_AGCK_PIF_1 | KPCB_HUMAN | 656 | 661 | Binary | Physicochemical compatibility | Dephosphorylation of the PIF motif by PHLPP1/2 results in reduced stability and increased degradation of PKC. This is countered by autophosphorylation of the PIF motif, but mTORC2 might also contribute. | Curated | |
Ribosomal protein S6 kinase alpha-3 - RPS6KA3 - Mus musculus | ||||||||
| DOC_AGCK_PIF_1 | KS6A3_MOUSE | 382 | 387 | Binary | Physicochemical compatibility | Auto-phosphorylation of S386 in the PIF pocket-binding motif of Ribosomal protein S6 kinase alpha-3 (Rps6ka3) induces intramolecular binding and kinase cis-activation. | Curated | |
Serine/threonine-protein kinase TOR1 - TOR1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | ||||||||
| DOC_AGCK_PIF_1 | SCH9_YEAST | 733 | 738 | Binary | Physicochemical compatibility | Phosphorylation of T737 by Serine/threonine-protein kinase TOR1 (TOR1) in the PIF pocket-binding motif of Serine/threonine-protein kinase SCH9 (SCH9) induces intramolecular binding and kinase cis-activation. | Curated | |
Serine/threonine-protein kinase mTOR - MTOR - Homo sapiens | ||||||||
| DOC_AGCK_PIF_1 | AKT1_HUMAN | 469 | 474 | Binary | Physicochemical compatibility | Phosphorylation of S473 in the PIF motif of RAC-alpha serine/threonine-protein kinase (AKT1) by Serine/threonine-protein kinase mTOR (MTOR) (as part of mTORC2 complex) induces intramolecular interaction with the PIF-binding pocket, resulting in cis-activation of RAC-alpha serine/threonine-protein kinase (AKT1). Dephosphorylation of the PIF motif by PHLPP1/2 (PHLPP1 for Akt2/3 and PHLPP2 for Akt1/3) results in reduced Akt activity, probably by disrupting the interaction with the Akt PIF pocket and thus cis-activation. | Curated | |
| DOC_AGCK_PIF_1 | SGK1_HUMAN | 418 | 423 | Binary | Physicochemical compatibility | Phosphorylation of S422 by Serine/threonine-protein kinase mTOR (MTOR) (as part of mTORC2 complex) in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk1 (SGK1) induces intramolecular binding and kinase cis-activation. | Curated | |