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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Protein kinase C beta type - PRKCB - Homo sapiens | |||||||
| DOC_AGCK_PIF_1 | 656 | 661 | Binary | Physicochemical compatibility | Dephosphorylation of the PIF motif by PHLPP1/2 results in reduced stability and increased degradation of PKC. This is countered by autophosphorylation of the PIF motif, but mTORC2 might also contribute. | ||
RAC-alpha serine/threonine-protein kinase - AKT1 - Homo sapiens | |||||||
| DOC_AGCK_PIF_1 | 469 | 474 | Binary | Physicochemical compatibility | Phosphorylation of S473 in the PIF motif of RAC-alpha serine/threonine-protein kinase (AKT1) by Serine/threonine-protein kinase mTOR (MTOR) (as part of mTORC2 complex) induces intramolecular interaction with the PIF-binding pocket, resulting in cis-activation of RAC-alpha serine/threonine-protein kinase (AKT1). Dephosphorylation of the PIF motif by PHLPP1/2 (PHLPP1 for Akt2/3 and PHLPP2 for Akt1/3) results in reduced Akt activity, probably by disrupting the interaction with the Akt PIF pocket and thus cis-activation. | ||
RAC-beta serine/threonine-protein kinase - AKT2 - Homo sapiens | |||||||
| DOC_AGCK_PIF_1 | 470 | 475 | Binary | Physicochemical compatibility | Phosphorylation of S474 in the PIF pocket-binding motif of RAC-beta serine/threonine-protein kinase (AKT2) induces intramolecular binding and kinase cis-activation. | ||
Rho-associated protein kinase 1 - ROCK1 - Homo sapiens | |||||||
| DOC_AGCK_PIF_1 | 394 | 399 | Binary | Physicochemical compatibility | Phosphorylation of T398 in the PIF pocket-binding motif of Rho-associated protein kinase 1 (ROCK1) induces intramolecular binding and kinase cis-activation. | ||
Ribosomal protein S6 kinase alpha-3 - Rps6ka3 - Mus musculus | |||||||
| DOC_AGCK_PIF_1 | 382 | 387 | Binary | Physicochemical compatibility | Auto-phosphorylation of S386 in the PIF pocket-binding motif of Ribosomal protein S6 kinase alpha-3 (Rps6ka3) induces intramolecular binding and kinase cis-activation. | ||
Ribosomal protein S6 kinase beta-1 - Rps6kb1 - Rattus norvegicus | |||||||
| DOC_AGCK_PIF_1 | 408 | 413 | Binary | Physicochemical compatibility | Phosphorylation of T412 in the PIF pocket-binding motif of Ribosomal protein S6 kinase beta-1 (Rps6kb1) induces intramolecular binding and kinase cis-activation. | ||
Serine/threonine-protein kinase SCH9 - SCH9 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | |||||||
| DOC_AGCK_PIF_1 | 733 | 738 | Binary | Physicochemical compatibility | Phosphorylation of T737 by Serine/threonine-protein kinase TOR1 (TOR1) in the PIF pocket-binding motif of Serine/threonine-protein kinase SCH9 (SCH9) induces intramolecular binding and kinase cis-activation. | ||
Serine/threonine-protein kinase Sgk1 - SGK1 - Homo sapiens | |||||||
| DOC_AGCK_PIF_1 | 418 | 423 | Binary | Physicochemical compatibility | Phosphorylation of S422 by Serine/threonine-protein kinase mTOR (MTOR) (as part of mTORC2 complex) in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk1 (SGK1) induces intramolecular binding and kinase cis-activation. | ||
Serine/threonine-protein kinase Sgk3 - SGK3 - Homo sapiens | |||||||
| DOC_AGCK_PIF_1 | 482 | 487 | Binary | Physicochemical compatibility | Phosphorylation of S486 in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk3 (SGK3) induces intramolecular binding and kinase cis-activation. | ||
Serine/threonine-protein kinase Sgk3 - Sgk3 - Mus musculus | |||||||
| DOC_AGCK_PIF_1 | 482 | 487 | Binary | Physicochemical compatibility | Phosphorylation of S486 in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk3 (Sgk3) induces intramolecular binding and kinase cis-activation. | ||