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ELM:LIG_PDZ_Class_1 (4 hits)
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Index
Beta-adrenergic receptor kinase 1
G protein-coupled receptor kinase 5
cAMP subfamily
()
Motif
Protein
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End
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Information
Evidence
cAMP subfamily
LIG_PDZ_Class_1
CCG2_MOUSE
318
323
Binary
Physicochemical compatibility
Phosphorylation of T321 in the PDZ-binding motif of
Voltage-dependent calcium channel gamma-2 subunit (Cacng2)
by
cAMP subfamily
prevents binding to the PDZ domain of
Disks large homolog 4 (Dlg4)
, an interaction involved in regulating synaptic targeting of AMPA-selective glutamate receptors.
details
Curated
LIG_PDZ_Class_1
IRK4_HUMAN
440
445
Binary
Physicochemical compatibility
Phosphorylation of S443 in the PDZ-binding motif of
Inward rectifier potassium channel 4 (KCNJ4)
by inhibits its interaction with the
Disks large homolog 4 (DLG4)
protein.
details
Curated
Beta-adrenergic receptor kinase 1 -
ADRBK1
-  
Homo sapiens
LIG_PDZ_Class_1
PGFRB_HUMAN
1101
1106
Binary
Physicochemical compatibility
Phosphorylation of S1104 in the PDZ-binding motif of
Platelet-derived growth factor receptor beta (PDGFRB)
by
Beta-adrenergic receptor kinase 1 (ADRBK1)
inhibits binding to
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
. Binding of
Platelet-derived growth factor receptor beta (PDGFRB)
to
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.
details
Curated
G protein-coupled receptor kinase 5 -
GRK5
-  
Homo sapiens
LIG_PDZ_Class_1
ADRB2_HUMAN
408
413
Binary
Physicochemical compatibility
Phosphorylation of S411 in the PDZ-binding motif of
Beta-2 adrenergic receptor (ADRB2)
by inhibits its interaction with the
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
protein.
details
Curated