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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF00595 (6 hits) x


x  Coloured by: Modifier evidence source
          Curated          inferred


x  Index
Beta-adrenergic receptor kinase 1Beta-adrenergic receptor kinase 1 (Bos)G protein-coupled receptor kinase 5
cAMP subfamily ()cAMP-dependent protein kinase catalytic subunit alpha (Mus)


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

cAMP subfamily
LIG_PDZ_Class_1 CCG2_MOUSE318323BinaryPhysicochemical compatibilityPhosphorylation of T321 in the PDZ-binding motif of Voltage-dependent calcium channel gamma-2 subunit (Cacng2) by cAMP subfamily prevents binding to the PDZ domain of Disks large homolog 4 (Dlg4), an interaction involved in regulating synaptic targeting of AMPA-selective glutamate receptors.
details
Curated
LIG_PDZ_Class_1 IRK4_HUMAN440445BinaryPhysicochemical compatibilityPhosphorylation of S443 in the PDZ-binding motif of Inward rectifier potassium channel 4 (KCNJ4) by inhibits its interaction with the Disks large homolog 4 (DLG4) protein.
details
Curated

Beta-adrenergic receptor kinase 1 - ADRBK1 -  Bos taurus
LIG_PDZ_Class_1 PGFRB_HUMAN11011106BinaryPhysicochemical compatibilityPhosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.
details
Inferred

Beta-adrenergic receptor kinase 1 - ADRBK1 -  Homo sapiens
LIG_PDZ_Class_1 PGFRB_HUMAN11011106BinaryPhysicochemical compatibilityPhosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.
details
Curated

G protein-coupled receptor kinase 5 - GRK5 -  Homo sapiens
LIG_PDZ_Class_1 ADRB2_HUMAN408413BinaryPhysicochemical compatibilityPhosphorylation of S411 in the PDZ-binding motif of Beta-2 adrenergic receptor (ADRB2) by inhibits its interaction with the Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) protein.
details
Curated

cAMP-dependent protein kinase catalytic subunit alpha - PRKACA -  Mus musculus
LIG_PDZ_Class_1 CCG2_MOUSE318323BinaryPhysicochemical compatibilityPhosphorylation of T321 in the PDZ-binding motif of Voltage-dependent calcium channel gamma-2 subunit (Cacng2) by cAMP subfamily prevents binding to the PDZ domain of Disks large homolog 4 (Dlg4), an interaction involved in regulating synaptic targeting of AMPA-selective glutamate receptors.
details
Inferred
           
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