About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:LIG_FHA_2 (11 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
DNA repair protein RAD9 (Saccharomyces)DNA repair protein XRCC1DNA repair protein XRCC4
DNA repair protein XRCC4 (Mus)MKI67 FHA domain-interacting nucleolar phosphoproteinMediator of replication checkpoint protein 1 (Schizosaccharomyces)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

DNA repair protein RAD9 - RAD9 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
LIG_FHA_2153159BinaryPhysicochemical compatibilityPhosphorylation of T155 in the FHA-binding motif of DNA repair protein RAD9 (RAD9) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.
details
LIG_FHA_2190196BinaryPhysicochemical compatibilityPhosphorylation of T192 in the FHA-binding motif of DNA repair protein RAD9 (RAD9) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.
details

DNA repair protein XRCC1 - XRCC1 -  Homo sapiens
LIG_FHA_2521527BinaryPhysicochemical compatibilityPhosphorylation of T523 in the FHA-binding motif of DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Aprataxin (APTX) protein.
details
LIG_FHA_2517
521		523
527		CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
LIG_FHA_2517523Avidity‑sensingHierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).
details
LIG_FHA_2521527Avidity‑sensingHierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).
details

DNA repair protein XRCC4 - XRCC4 -  Homo sapiens
LIG_FHA_2231237BinaryPhysicochemical compatibilityPhosphorylation of T233 in the FHA-binding motif of DNA repair protein XRCC4 (XRCC4) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Bifunctional polynucleotide phosphatase/kinase (PNKP) protein.
details

DNA repair protein XRCC4 - Xrcc4 -  Mus musculus
LIG_FHA_2229235BinaryPhysicochemical compatibilityPhosphorylation of T231 in the FHA-binding motif of DNA repair protein XRCC4 (Xrcc4) induces binding to the Bifunctional polynucleotide phosphatase/kinase (Pnkp) protein.
details

MKI67 FHA domain-interacting nucleolar phosphoprotein - MKI67IP -  Homo sapiens
LIG_FHA_2238244SpecificityAltered binding specificityPhosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67).
details
LIG_FHA_2238244CumulativeRheostaticPhosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details
details

Mediator of replication checkpoint protein 1 - mrc1 -  Schizosaccharomyces pombe (strain 972 / ATCC 24843)
LIG_FHA_2643649BinaryPhysicochemical compatibilityPhosphorylation of T645 in the FHA-binding motif of Mediator of replication checkpoint protein 1 (mrc1) induces binding to the Serine/threonine-protein kinase cds1 (cds1) protein.
details
           
Please send any suggestions/comments to: switches@elm.eu.org