switches.ELM

Predicted switches in the ELMs Resource

General :Overview Visualisation Statistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificity Competition Domain hiding Motif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : Allostery Physicochemical compatibility Pre-translational Defined PTM-induced

Avidity - Avidity-sensing

Multiple low-affinity interactions give rise to high-avidity interactions that have increased binding strength, with more than additive affinity.

Accession	Protein	Gene	Motif	Start	Stop	Vis
Q24212	Protein stoned-B	stnB	LIG_EH_1	2	6	view
Q24212	Protein stoned-B	stnB	LIG_EH_1	18	22	view
Q24212	Protein stoned-B	stnB	LIG_EH_1	32	36	view
Q24212	Protein stoned-B	stnB	LIG_EH_1	42	46	view
Q24212	Protein stoned-B	stnB	LIG_EH_1	209	213	view
Q24212	Protein stoned-B	stnB	LIG_EH_1	492	496	view
Q24212	Protein stoned-B	stnB	LIG_EH_1	672	676	view
P52594	Arf-GAP domain and FG repeat-containing protein 1	AGFG1	LIG_EH_1	558	562	view
P52594	Arf-GAP domain and FG repeat-containing protein 1	AGFG1	LIG_EH_1	539	543	view
P52594	Arf-GAP domain and FG repeat-containing protein 1	AGFG1	LIG_EH_1	433	437	view
P52594	Arf-GAP domain and FG repeat-containing protein 1	AGFG1	LIG_EH_1	448	452	view
Q8CHU3	Epsin-2	Epn2	LIG_EH_1	493	497	view
Q8CHU3	Epsin-2	Epn2	LIG_EH_1	507	511	view
Q8CHU3	Epsin-2	Epn2	LIG_EH_1	590	594	view
P26045	Tyrosine-protein phosphatase non-receptor type 3	PTPN3	LIG_14-3-3_3	356	361	view
P26045	Tyrosine-protein phosphatase non-receptor type 3	PTPN3	LIG_14-3-3_3	832	837	view
P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	LIG_SH3_2	305	310	view
P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	LIG_SH3_2	308	313	view
P15391	B-lymphocyte antigen CD19	CD19	LIG_SH2_GRB2	348	351	view
P15391	B-lymphocyte antigen CD19	CD19	LIG_SH2_GRB2	378	381	view
Q05140	Clathrin coat assembly protein AP180	Snap91	LIG_AP2alpha_2	400	402	view
Q05140	Clathrin coat assembly protein AP180	Snap91	LIG_AP2alpha_2	474	476	view
P35568	Insulin receptor substrate 1	IRS1	LIG_14-3-3_3	267	272	view
P35568	Insulin receptor substrate 1	IRS1	LIG_14-3-3_3	371	376	view
P35568	Insulin receptor substrate 1	IRS1	LIG_14-3-3_3	638	643	view
P04049	RAF proto-oncogene serine/threonine-protein kinase	RAF1	LIG_14-3-3_1	256	261	view
P04049	RAF proto-oncogene serine/threonine-protein kinase	RAF1	LIG_14-3-3_1	618	623	view
Q90738	Actin filament-associated protein 1	AFAP1	LIG_SH2_SRC	94	97	view
Q90738	Actin filament-associated protein 1	AFAP1	LIG_SH2_SRC	451	454	view
Q90738	Actin filament-associated protein 1	AFAP1	LIG_SH2_SRC	453	456	view
Q9Y6I3	Epsin-1	EPN1	LIG_EH_1	501	505	view
Q9Y6I3	Epsin-1	EPN1	LIG_EH_1	517	521	view
Q9Y6I3	Epsin-1	EPN1	LIG_EH_1	571	575	view
O95208	Epsin-2	EPN2	LIG_EH_1	536	540	view
O95208	Epsin-2	EPN2	LIG_EH_1	551	555	view
O95208	Epsin-2	EPN2	LIG_EH_1	636	640	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	831	836	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	854	859	view
O95081	Arf-GAP domain and FG repeat-containing protein 2	AGFG2	LIG_EH_1	365	369	view
O95081	Arf-GAP domain and FG repeat-containing protein 2	AGFG2	LIG_EH_1	380	384	view
O95081	Arf-GAP domain and FG repeat-containing protein 2	AGFG2	LIG_EH_1	458	462	view
O95081	Arf-GAP domain and FG repeat-containing protein 2	AGFG2	LIG_EH_1	477	481	view
Q9H1K0	Rabenosyn-5	ZFYVE20	LIG_EH_1	625	629	view
Q9H1K0	Rabenosyn-5	ZFYVE20	LIG_EH_1	661	665	view
Q9H1K0	Rabenosyn-5	ZFYVE20	LIG_EH_1	676	680	view
Q9H1K0	Rabenosyn-5	ZFYVE20	LIG_EH_1	687	691	view
Q9H1K0	Rabenosyn-5	ZFYVE20	LIG_EH_1	708	712	view
Q9H1K0	Rabenosyn-5	ZFYVE20	LIG_EH_1	717	721	view
Q9N2H0	Cytochrome b-245 light chain	CYBA	LIG_SH3_3	154	160	view
Q9N2H0	Cytochrome b-245 light chain	CYBA	LIG_SH3_3	149	155	view
Q9N2H0	Cytochrome b-245 light chain	CYBA	LIG_SH3_3	153	159	view
Q9QY17	Protein kinase C and casein kinase substrate in neurons 2 protein	Pacsin2	LIG_EH_1	363	367	view
Q9QY17	Protein kinase C and casein kinase substrate in neurons 2 protein	Pacsin2	LIG_EH_1	406	410	view
Q9QY17	Protein kinase C and casein kinase substrate in neurons 2 protein	Pacsin2	LIG_EH_1	418	422	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_SRC	1349	1352	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_SRC	1356	1359	view
Q80VP1	Epsin-1	Epn1	LIG_EH_1	500	504	view
Q80VP1	Epsin-1	Epn1	LIG_EH_1	516	520	view
Q80VP1	Epsin-1	Epn1	LIG_EH_1	570	574	view
Q06187	Tyrosine-protein kinase BTK	BTK	LIG_SH3_1	186	192	view
Q06187	Tyrosine-protein kinase BTK	BTK	LIG_SH3_1	200	206	view
O54957	Linker for activation of T-cells family member 1	Lat	LIG_SH2_GRB2	175	178	view
O54957	Linker for activation of T-cells family member 1	Lat	LIG_SH2_GRB2	195	198	view
O54957	Linker for activation of T-cells family member 1	Lat	LIG_SH2_GRB2	235	238	view
Q12518	Epsin-1	ENT1	LIG_EH_1	305	309	view
Q12518	Epsin-1	ENT1	LIG_EH_1	406	410	view
P10912	Growth hormone receptor	GHR	LIG_SH2_STAT5	627	630	view
P10912	Growth hormone receptor	GHR	LIG_SH2_STAT5	566	569	view
P10912	Growth hormone receptor	GHR	LIG_SH2_STAT5	534	537	view
Q27974	Putative tyrosine-protein phosphatase auxilin	DNAJC6	LIG_AP2alpha_2	579	581	view
Q27974	Putative tyrosine-protein phosphatase auxilin	DNAJC6	LIG_AP2alpha_2	605	607	view
Q27974	Putative tyrosine-protein phosphatase auxilin	DNAJC6	LIG_AP2alpha_2	674	676	view
Q61097	Kinase suppressor of Ras 1	Ksr1	LIG_14-3-3_3	294	299	view
Q61097	Kinase suppressor of Ras 1	Ksr1	LIG_14-3-3_3	389	394	view
P32927	Cytokine receptor common subunit beta	CSF2RB	LIG_SH2_STAT5	628	631	view
P32927	Cytokine receptor common subunit beta	CSF2RB	LIG_SH2_STAT5	766	769	view
P00533	Epidermal growth factor receptor	EGFR	LIG_SH2_SRC	1016	1019	view
P00533	Epidermal growth factor receptor	EGFR	LIG_SH2_SRC	1125	1128	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	274	276	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	294	296	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	306	308	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	319	321	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	332	334	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	349	351	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	367	369	view
O88339	Epsin-1	Epn1	LIG_AP2alpha_2	377	379	view
O88339	Epsin-1	Epn1	LIG_EH_1	500	504	view
O88339	Epsin-1	Epn1	LIG_EH_1	516	520	view
O88339	Epsin-1	Epn1	LIG_EH_1	570	574	view
P56603	Secretory carrier-associated membrane protein 1	Scamp1	LIG_EH_1	6	10	view
P56603	Secretory carrier-associated membrane protein 1	Scamp1	LIG_EH_1	15	19	view
P56603	Secretory carrier-associated membrane protein 1	Scamp1	LIG_EH_1	37	41	view
Q3I768	RAB11-FIP2 long isoform	RAB11FIP2	LIG_EH_1	322	326	view
Q3I768	RAB11-FIP2 long isoform	RAB11FIP2	LIG_EH_1	405	409	view
Q3I768	RAB11-FIP2 long isoform	RAB11FIP2	LIG_EH_1	459	463	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	672	674	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	692	694	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	709	711	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	737	739	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	599	601	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	623	625	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	629	631	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	634	636	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	640	642	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	645	647	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	651	653	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	664	666	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	798	800	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	804	806	view
P42566	Epidermal growth factor receptor substrate 15	EPS15	LIG_AP2alpha_2	825	827	view
Q13492	Phosphatidylinositol-binding clathrin assembly protein	PICALM	LIG_EH_1	436	440	view
Q13492	Phosphatidylinositol-binding clathrin assembly protein	PICALM	LIG_EH_1	638	642	view
P38856	Clathrin coat assembly protein AP180A	YAP1801	LIG_EH_1	336	340	view
P38856	Clathrin coat assembly protein AP180A	YAP1801	LIG_EH_1	362	366	view
P38856	Clathrin coat assembly protein AP180A	YAP1801	LIG_EH_1	456	460	view
P38856	Clathrin coat assembly protein AP180A	YAP1801	LIG_EH_1	479	483	view
P38856	Clathrin coat assembly protein AP180A	YAP1801	LIG_EH_1	502	506	view
P40189	Interleukin-6 receptor subunit beta	IL6ST	LIG_SH2_STAT3	767	770	view
P40189	Interleukin-6 receptor subunit beta	IL6ST	LIG_SH2_STAT3	814	817	view
P40189	Interleukin-6 receptor subunit beta	IL6ST	LIG_SH2_STAT3	905	908	view
P40189	Interleukin-6 receptor subunit beta	IL6ST	LIG_SH2_STAT3	915	918	view
Q05785	Epsin-2	ENT2	LIG_EH_1	346	350	view
Q05785	Epsin-2	ENT2	LIG_EH_1	490	494	view
P56945	Breast cancer anti-estrogen resistance protein 1	BCAR1	LIG_SH2_SRC	653	656	view
P56945	Breast cancer anti-estrogen resistance protein 1	BCAR1	LIG_SH2_SRC	664	667	view
Q8IPH9	Slowpoke-binding protein	Slob	LIG_14-3-3_3	51	56	view
Q8IPH9	Slowpoke-binding protein	Slob	LIG_14-3-3_3	76	81	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	599	601	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	618	620	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	624	626	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	629	631	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	640	642	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	645	647	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	656	658	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	661	663	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	667	669	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	685	687	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	690	692	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	703	705	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	709	711	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	722	724	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	728	730	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	768	770	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	812	814	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	823	825	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	833	835	view
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	EPS15L1	LIG_AP2alpha_2	839	841	view
P53309	Clathrin coat assembly protein AP180B	YAP1802	LIG_EH_1	339	343	view
P53309	Clathrin coat assembly protein AP180B	YAP1802	LIG_EH_1	372	376	view
P53309	Clathrin coat assembly protein AP180B	YAP1802	LIG_EH_1	452	456	view
P53309	Clathrin coat assembly protein AP180B	YAP1802	LIG_EH_1	473	477	view
P53309	Clathrin coat assembly protein AP180B	YAP1802	LIG_EH_1	493	497	view
O43524	Forkhead box protein O3	FOXO3	LIG_14-3-3_3	29	34	view
O43524	Forkhead box protein O3	FOXO3	LIG_14-3-3_3	250	255	view
P19235	Erythropoietin receptor	EPOR	LIG_SH2_STAT5	426	429	view
P19235	Erythropoietin receptor	EPOR	LIG_SH2_STAT5	368	371	view
Q62910	Synaptojanin-1	Synj1	LIG_EH_1	1400	1404	view
Q62910	Synaptojanin-1	Synj1	LIG_EH_1	1409	1413	view
Q62910	Synaptojanin-1	Synj1	LIG_EH_1	1420	1424	view
Q8WXE9	Stonin-2	STON2	LIG_EH_1	312	316	view
Q8WXE9	Stonin-2	STON2	LIG_EH_1	328	332	view
O55012	Phosphatidylinositol-binding clathrin assembly protein	Picalm	LIG_EH_1	429	433	view
O55012	Phosphatidylinositol-binding clathrin assembly protein	Picalm	LIG_EH_1	626	630	view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	view
P29353	SHC-transforming protein 1	SHC1	LIG_SH2_GRB2	349	352	view
P29353	SHC-transforming protein 1	SHC1	LIG_SH2_GRB2	427	430	view
Q07889	Son of sevenless homolog 1	SOS1	LIG_SH3_2	1151	1156	view
Q07889	Son of sevenless homolog 1	SOS1	LIG_SH3_2	1152	1157	view
Q8NDI1	EH domain-binding protein 1	EHBP1	LIG_EH_1	267	271	view
Q8NDI1	EH domain-binding protein 1	EHBP1	LIG_EH_1	278	282	view
Q8NDI1	EH domain-binding protein 1	EHBP1	LIG_EH_1	308	312	view
Q8NDI1	EH domain-binding protein 1	EHBP1	LIG_EH_1	320	324	view
Q8NDI1	EH domain-binding protein 1	EHBP1	LIG_EH_1	369	373	view
Q9Z0W5	Protein kinase C and casein kinase substrate in neurons protein 1	Pacsin1	LIG_EH_1	363	367	view
Q9Z0W5	Protein kinase C and casein kinase substrate in neurons protein 1	Pacsin1	LIG_EH_1	375	379	view