switches.ELM

Predicted switches in the ELMs Resource

General :Overview Visualisation Statistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificity Competition Domain hiding Motif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : Allostery Physicochemical compatibility Pre-translational Defined PTM-induced

Binary - Allostery

The binding properties of a motif or a motif-binding domain are modulated indirectly by allosteric effects resulting from PTM or effector binding at a site that is distinct from the actual interaction interface.

Accession	Protein	Gene	Motif	Start	Stop	Vis
Q90ZL7	Prospero-related homeodomain protein 1	prox1a	LIG_NRBOX	69	75	view
P32004	Neural cell adhesion molecule L1	L1CAM	TRG_ENDOCYTIC_2	1176	1179	view
P09693	T-cell surface glycoprotein CD3 gamma chain	CD3G	TRG_LysEnd_APsAcLL_1	149	154	view
P56817	Beta-secretase 1	BACE1	TRG_LysEnd_APsAcLL_1	495	500	view
O15118	Niemann-Pick C1 protein	NPC1	TRG_LysEnd_APsAcLL_1	1271	1276	view
P41143	Delta-type opioid receptor	OPRD1	TRG_LysEnd_APsAcLL_1	241	246	view
P01730	T-cell surface glycoprotein CD4	CD4	TRG_LysEnd_APsAcLL_1	434	439	view
Q15648	Mediator of RNA polymerase II transcription subunit 1	MED1	LIG_NRBOX	603	609	view
Q15648	Mediator of RNA polymerase II transcription subunit 1	MED1	LIG_NRBOX	644	650	view
P19814	Trans-Golgi network integral membrane protein TGN38	Ttgn1	TRG_ENDOCYTIC_2	350	353	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	20	26	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	132	138	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	184	190	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	265	271	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	379	385	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	499	505	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	500	506	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	712	718	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	818	824	view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	935	941	view
Q9UQ80	Proliferation-associated protein 2G4	PA2G4	LIG_NRBOX	353	359	view
P03522	Glycoprotein G	G	TRG_ENDOCYTIC_2	501	504	view
O43593	Protein hairless	HR	LIG_NRBOX	565	571	view
O43593	Protein hairless	HR	LIG_NRBOX	757	763	view
P04578	Envelope glycoprotein gp160	env	TRG_ENDOCYTIC_2	712	715	view
Q9Y618	Nuclear receptor corepressor 2	NCOR2	LIG_CORNRBOX	2143	2151	view
Q9Y618	Nuclear receptor corepressor 2	NCOR2	LIG_CORNRBOX	2350	2358	view
P11117	Lysosomal acid phosphatase	ACP2	TRG_ENDOCYTIC_2	413	416	view
P04235	T-cell surface glycoprotein CD3 delta chain	Cd3d	TRG_LysEnd_APsAcLL_1	138	143	view
P04233	HLA class II histocompatibility antigen gamma chain	CD74	TRG_LysEnd_APsAcLL_1	19	24	view
P09793	Cytotoxic T-lymphocyte protein 4	Ctla4	TRG_ENDOCYTIC_2	201	204	view
P00533	Epidermal growth factor receptor	EGFR	TRG_ENDOCYTIC_2	998	1001	view
Q9J3M8	Envelope glycoprotein E	gE	TRG_ENDOCYTIC_2	582	585	view
P50895	Basal cell adhesion molecule	BCAM	TRG_LysEnd_APsAcLL_1	604	609	view
P16410	Cytotoxic T-lymphocyte protein 4	CTLA4	TRG_ENDOCYTIC_2	201	204	view
Q9UBK2	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	PPARGC1A	LIG_NRBOX	143	149	view
P04601	Nef protein	nef	TRG_LysEnd_APsAcLL_1	160	165	view
Q9JL19	Nuclear receptor coactivator 6	Ncoa6	LIG_NRBOX	1494	1500	view
Q92793	CREB-binding protein	CREBBP	LIG_NRBOX	69	75	view
P14142	Solute carrier family 2, facilitated glucose transporter member 4	Slc2a4	TRG_LysEnd_APsAcLL_1	485	490	view
P16070	CD44 antigen	CD44	TRG_LysEnd_APsAcLL_1	708	713	view
P07306	Asialoglycoprotein receptor 1	ASGR1	TRG_ENDOCYTIC_2	5	8	view
P03383	Envelope glycoprotein gp63	env	TRG_ENDOCYTIC_2	477	480	view
Q04656	Copper-transporting ATPase 1	ATP7A	TRG_LysEnd_APsAcLL_1	1483	1488	view
P11942	T-cell surface glycoprotein CD3 gamma chain	Cd3g	TRG_LysEnd_APsAcLL_1	149	154	view
P02786	Transferrin receptor protein 1	TFRC	TRG_ENDOCYTIC_2	20	23	view
P05855	Protein Nef	nef	TRG_LysEnd_APsAcLL_1	159	164	view
P05884	Envelope glycoprotein gp160	env	TRG_ENDOCYTIC_2	723	726	view
P51519	Envelope glycoprotein	env	TRG_ENDOCYTIC_2	487	490	view
P51519	Envelope glycoprotein	env	TRG_LysEnd_APsAcLL_1	463	468	view
Q15596	Nuclear receptor coactivator 2	NCOA2	LIG_NRBOX	640	646	view
Q15596	Nuclear receptor coactivator 2	NCOA2	LIG_NRBOX	689	695	view
Q15596	Nuclear receptor coactivator 2	NCOA2	LIG_NRBOX	744	750	view
O75376	Nuclear receptor corepressor 1	NCOR1	LIG_CORNRBOX	2051	2059	view
O75376	Nuclear receptor corepressor 1	NCOR1	LIG_CORNRBOX	2263	2271	view
P11279	Lysosome-associated membrane glycoprotein 1	LAMP1	TRG_ENDOCYTIC_2	414	417	view