switches.ELM

Predicted switches in the ELMs Resource

General :Overview Visualisation Statistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificity Competition Domain hiding Motif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : Allostery Physicochemical compatibility Pre-translational Defined PTM-induced

Binary - Defined

Binary - Physicochemical compatibility type switch that is modified on a specific defined position of the motif necessary to induce partner domain binding (e.g. SH2, PTB domain binding motifs).

Accession	Protein	Gene	Motif	Start	Stop	Flanking	Overlap	Defined	Modified	Vis
Q15691	Microtubule-associated protein RP/EB family member 1	MAPRE1	LIG_CAP-Gly_1	263	268			267		view
P31749	RAC-alpha serine/threonine-protein kinase	AKT1	LIG_AGCK_PIF_1	469	474	+0, +2, +4		472, 473		view
Q13111	Chromatin assembly factor 1 subunit A	CHAF1A	LIG_HP1_1	238	242	-1		240		view
Q13291	Signaling lymphocytic activation molecule	SLAMF1	MOD_TYR_ITSM	277	284		276	278	280	view
O00141	Serine/threonine-protein kinase Sgk1	SGK1	LIG_AGCK_PIF_1	418	423			421		view
Q8C351	Layilin	Layn	LIG_PTB_Apo_2	374	381		380	379		view
P32004	Neural cell adhesion molecule L1	L1CAM	TRG_ENDOCYTIC_2	1176	1179	+1		1175		view
Q12834	Cell division cycle protein 20 homolog	CDC20	LIG_MAD2	129	137		135	128		view
Q12834	Cell division cycle protein 20 homolog	CDC20	LIG_APCC_KENbox_2	96	100	+5		96		view
P05771	Protein kinase C beta type	PRKCB	LIG_AGCK_PIF_1	657	662			660		view
P26045	Tyrosine-protein phosphatase non-receptor type 3	PTPN3	LIG_14-3-3_3	356	361	+5		356	358	view
O75122	CLIP-associating protein 2	CLASP2	LIG_SxIP_EBH_1	492	502	+0, +4		498		view
O75122	CLIP-associating protein 2	CLASP2	LIG_SxIP_EBH_1	515	525	+3		515, 522, 524		view
P07766	T-cell surface glycoprotein CD3 epsilon chain	CD3E	LIG_SH3_5	184	188			187		view
Q9UQF2	C-Jun-amino-terminal kinase-interacting protein 1	MAPK8IP1	CLV_C14_Caspase3-7	405	409	+1		406, 408		view
O75533	Splicing factor 3B subunit 1	SF3B1	LIG_ULM_U2AF65_1	195	201	-1, +1, +5		194		view
O75533	Splicing factor 3B subunit 1	SF3B1	LIG_ULM_U2AF65_1	333	339	-1, +1, +4		332		view
Q16665	Hypoxia-inducible factor 1-alpha	HIF1A	LIG_KEPE_2	476	483			476		view
Q9H4A3	Serine/threonine-protein kinase WNK1	WNK1	LIG_SPAK-OSR1_1	1957	1961	+1		1958		view
Q14106	Protein Tob2	TOB2	LIG_PAM2_1	251	263			253		view
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	CLV_C14_Caspase3-7	381	385	-1		381, 382, 384		view
P06400	Retinoblastoma-associated protein	RB1	LIG_CYCLIN_1	873	877	+4	873	872		view
P06400	Retinoblastoma-associated protein	RB1	TRG_NLS_Bipartite_1	860	877	+4		872, 873		view
P06400	Retinoblastoma-associated protein	RB1	CLV_C14_Caspase3-7	346	350	+2, +5		346, 349		view
P06400	Retinoblastoma-associated protein	RB1	LIG_PP1	872	878	+3	872	873		view
P35568	Insulin receptor substrate 1	IRS1	LIG_14-3-3_3	267	272	+0, +1		267, 271	269	view
P35568	Insulin receptor substrate 1	IRS1	LIG_14-3-3_3	638	643			638		view
P41743	Protein kinase C iota type	PRKCI	LIG_AGCK_PIF_2	579	584			583		view
P62024	Phosphatase and actin regulator 1	Phactr1	LIG_Actin_RPEL_3	462	481			466		view
P62024	Phosphatase and actin regulator 1	Phactr1	LIG_Actin_RPEL_3	500	519	+5	508	504		view
Q99661	Kinesin-like protein KIF2C	KIF2C	LIG_SxIP_EBH_1	93	104	+1, +4		94		view
Q16828	Dual specificity protein phosphatase 6	DUSP6	LIG_MAPK_1	64	73			67		view
Q9P270	SLAIN motif-containing protein 2	SLAIN2	LIG_CAP-Gly_2	575	581			580		view
P05412	Transcription factor AP-1	JUN	LIG_KEPE_3	225	234	+4	230	225		view
P05412	Transcription factor AP-1	JUN	MOD_GSK3_1	236	243	+5		242	238	view
Q13188	Serine/threonine-protein kinase 3	STK3	CLV_C14_Caspase3-7	319	323			322		view
P04049	RAF proto-oncogene serine/threonine-protein kinase	RAF1	LIG_14-3-3_1	256	261		256	257, 259	258	view
Q90738	Actin filament-associated protein 1	AFAP1	LIG_SH2_SRC	451	454			452	450	view
P25054	Adenomatous polyposis coli protein	APC	TRG_NLS_MonoExtN_4	2048	2054			2053		view
Q9Y6I3	Epsin-1	EPN1	TRG_AP2beta_CARGO_1	402	411	+4, +5		409		view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Apo_2	4467	4474			4472		view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Apo_2	4501	4508	+2		4506		view
Q04206	Transcription factor p65	RELA	TRG_NLS_MonoExtC_3	301	307	+0, +2, +3		304		view
Q71U36	Tubulin alpha-1A chain	TUBA1A	LIG_CAP-Gly_1	443	451			450		view
Q00987	E3 ubiquitin-protein ligase Mdm2	MDM2	LIG_USP7_1	226	230			228		view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Apo_2	767	774	+2, +3, +4		772		view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Apo_2	779	786	-1	778, 783	784		view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	831	836			831	833	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	854	859		857	854	856	view
P05107	Integrin beta-2	ITGB2	LIG_14-3-3_3	755	760		758	754, 755, 759	757	view
Q61214	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Dyrk1a	MOD_TYR_DYR	315	325			318, 323	320	view
P09619	Platelet-derived growth factor receptor beta	PDGFRB	LIG_PDZ_Class_1	1101	1106			1103		view
Q9UKG1	DCC-interacting protein 13-alpha	APPL1	LIG_OCRL_FandH_1	403	415		402	409		view
Q9Z188	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Dyrk1b	MOD_TYR_DYR	267	277			270, 275	272	view
Q9H2X6	Homeodomain-interacting protein kinase 2	HIPK2	LIG_KEPE_3	31	40			31		view
O60315	Zinc finger E-box-binding homeobox 2	ZEB2	LIG_CtBP_PxDLS_1	815	819			818		view
Q15797	Mothers against decapentaplegic homolog 1	SMAD1	MOD_GSK3_1	207	214	-1		213		view
Q15797	Mothers against decapentaplegic homolog 1	SMAD1	MOD_GSK3_1	199	206			205	201	view
O15525	Transcription factor MafG	MAFG	LIG_KEPE_1	13	19			13		view
Q16821	Protein phosphatase 1 regulatory subunit 3A	PPP1R3A	LIG_PP1	61	67			64		view
Q8R4T5	General receptor for phosphoinositides 1-associated scaffold protein	Grasp	LIG_PDZ_Class_1	389	394			391		view
P09016	Homeobox protein Hox-D4	HOXD4	LIG_HOMEOBOX	134	137			133		view
P48552	Nuclear receptor-interacting protein 1	NRIP1	LIG_NRBOX	184	190			186		view
P52566	Rho GDP-dissociation inhibitor 2	ARHGDIB	CLV_C14_Caspase3-7	16	20	+0, +3, +4		19		view
Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	LIG_IQ	1666	1685	+4		1682		view
P05067	Amyloid beta A4 protein	APP	LIG_PTB_Apo_2	756	763		760, 762	756, 761		view
P08592	Amyloid beta A4 protein	App	LIG_PTB_Apo_2	756	763			756, 761		view
Q06609	DNA repair protein RAD51 homolog 1	RAD51	LIG_SH3_1	315	321			314		view
Q9UQ80	Proliferation-associated protein 2G4	PA2G4	LIG_NRBOX	353	359	+0, +1, +3		354		view
Q91V27	Melanophilin	Mlph	LIG_SxIP_EBH_1	493	506			497		view
Q8IZP0	Abl interactor 1	ABI1	LIG_SH3_5	417	421			420		view
P30305	M-phase inducer phosphatase 2	CDC25B	LIG_14-3-3_3	320	325			320	322	view
Q61097	Kinase suppressor of Ras 1	Ksr1	LIG_14-3-3_3	389	394			389	391	view
Q00613	Heat shock factor protein 1	HSF1	MOD_GSK3_1	300	307			306	302	view
Q14118	Dystroglycan	DAG1	LIG_WW_1	889	892	-1		891		view
Q14118	Dystroglycan	DAG1	TRG_NLS_MonoExtN_4	778	783			779, 781		view
Q13043	Serine/threonine-protein kinase 4	STK4	TRG_NES_CRM1_1	359	374	+5	359	366		view
Q13043	Serine/threonine-protein kinase 4	STK4	CLV_C14_Caspase3-7	323	327	+1		326		view
Q13263	Transcription intermediary factor 1-beta	TRIM28	LIG_HP1_1	486	490			488		view
Q92738	USP6 N-terminal-like protein	USP6NL	LIG_SH3_5	725	729			728		view
P84022	Mothers against decapentaplegic homolog 3	SMAD3	MOD_GSK3_1	201	208	+4		207	203	view
P32926	Desmoglein-3	DSG3	CLV_C14_Caspase3-7	778	782			778		view
Q63470	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Dyrk1a	MOD_TYR_DYR	315	325			318	320	view
P09793	Cytotoxic T-lymphocyte protein 4	Ctla4	TRG_ENDOCYTIC_2	201	204			200		view
P00533	Epidermal growth factor receptor	EGFR	TRG_ENDOCYTIC_2	998	1001			997		view
Q9ERE3	Serine/threonine-protein kinase Sgk3	Sgk3	LIG_AGCK_PIF_1	482	487			485		view
P16410	Cytotoxic T-lymphocyte protein 4	CTLA4	TRG_ENDOCYTIC_2	201	204			200		view
P00740	Coagulation factor IX	F9	MOD_N-GLC_1	202	207			203		view
P12931	Proto-oncogene tyrosine-protein kinase Src	SRC	MOD_TYR_CSK	526	534	-1		525	529	view
P04637	Cellular tumor antigen p53	TP53	LIG_CYCLIN_1	381	385	+0, +1	381	380		view
P04637	Cellular tumor antigen p53	TP53	LIG_USP7_1	359	363	+2		361		view
P04637	Cellular tumor antigen p53	TP53	LIG_USP7_1	364	368	+1, +2, +3, +4		365		view
P04637	Cellular tumor antigen p53	TP53	TRG_NLS_Bipartite_1	305	323	+3	311, 312, 313, 314	304, 318, 319, 320		view
P04637	Cellular tumor antigen p53	TP53	MOD_GSK3_1	30	37			36	32	view
Q13950	Runt-related transcription factor 2	RUNX2	LIG_WRPW_1	518	521			520		view
Q13813	Spectrin alpha chain, non-erythrocytic 1	SPTAN1	CLV_C14_Caspase3-7	1182	1186	+0, +1, +3		1183, 1185		view
Q60591	Nuclear factor of activated T-cells, cytoplasmic 2	Nfatc2	LIG_PP2B_1	110	116		109	115		view
O15392	Baculoviral IAP repeat-containing protein 5	BIRC5	MOD_PKA_2	17	23		22	20	19	view
O88485	Cytoplasmic dynein 1 intermediate chain 1	Dync1i1	LIG_Dynein_DLC8_1	149	155	-1, +3	149	152, 154		view
P01130	Low-density lipoprotein receptor	LDLR	LIG_PTB_Apo_2	822	829	+0		827		view
Q14114	Low-density lipoprotein receptor-related protein 8	LRP8	LIG_PTB_Apo_2	860	867	+0		865		view
P22307	Non-specific lipid-transfer protein	SCP2	TRG_PTS1	544	547			545		view
P24864	G1/S-specific cyclin-E1	CCNE1	MOD_GSK3_1	392	399	-1		398	394	view
P18654	Ribosomal protein S6 kinase alpha-3	Rps6ka3	LIG_AGCK_PIF_1	382	387			385		view
P12023	Amyloid beta A4 protein	App	LIG_PTB_Apo_2	756	763			756, 761		view
P14316	Interferon regulatory factor 2	IRF2	LIG_KEPE_1	136	142			136		view
O35254	Golgi reassembly-stacking protein 1	Gorasp1	CLV_C14_Caspase3-7	372	376			375		view
P49715	CCAAT/enhancer-binding protein alpha	CEBPA	LIG_KEPE_1	160	166			160		view
P49715	CCAAT/enhancer-binding protein alpha	CEBPA	LIG_KEPE_2	160	168			160		view
P49715	CCAAT/enhancer-binding protein alpha	CEBPA	LIG_KEPE_3	160	169			160		view
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	DYRK1A	MOD_TYR_DYR	315	325			318, 323	320	view
P56524	Histone deacetylase 4	HDAC4	LIG_KEPE_2	558	566		564	558		view
P48436	Transcription factor SOX-9	SOX9	MOD_PKA_1	61	67			60	63	view
P52701	DNA mismatch repair protein Msh6	MSH6	LIG_PCNA_PIPBox_1	4	13	+0		7, 8		view
P39688	Tyrosine-protein kinase Fyn	Fyn	MOD_TYR_CSK	527	535			526	530	view
P54253	Ataxin-1	ATXN1	LIG_14-3-3_1	772	777			775	774	view
Q8WUM4	Programmed cell death 6-interacting protein	PDCD6IP	LIG_PTAP_UEV_1	716	721	+2, +5		717		view
P78363	Retinal-specific ATP-binding cassette transporter	ABCA4	MOD_N-GLC_1	1528	1533			1530		view
P07948	Tyrosine-protein kinase Lyn	LYN	MOD_TYR_CSK	504	512			503	507	view
P11387	DNA topoisomerase 1	TOP1	LIG_KEPE_2	116	123	+1		116		view
O88602	Voltage-dependent calcium channel gamma-2 subunit	Cacng2	LIG_PDZ_Class_1	318	323			320		view
O88602	Voltage-dependent calcium channel gamma-2 subunit	Cacng2	MOD_PKA_2	317	323			320		view
P54259	Atrophin-1	ATN1	CLV_C14_Caspase3-7	106	110	+1		106		view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	LIG_PCNA_PIPBox_1	144	153	+0	144, 152	145		view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	TRG_NLS_Bipartite_1	142	158	-1, +2, +4	144, 145	152, 153		view
P07306	Asialoglycoprotein receptor 1	ASGR1	TRG_ENDOCYTIC_2	5	8			4		view
P56945	Breast cancer anti-estrogen resistance protein 1	BCAR1	LIG_SH2_SRC	664	667			665	663	view
Q15303	Receptor tyrosine-protein kinase erbB-4	ERBB4	LIG_WW_1	1053	1056			1055		view
Q96BR1	Serine/threonine-protein kinase Sgk3	SGK3	LIG_AGCK_PIF_1	482	487			485		view
Q13541	Eukaryotic translation initiation factor 4E-binding protein 1	EIF4EBP1	LIG_eIF4E_1	54	60	+4		53		view
Q13542	Eukaryotic translation initiation factor 4E-binding protein 2	EIF4EBP2	LIG_eIF4E_1	54	60	+4		53		view
P01106	Myc proto-oncogene protein	MYC	TRG_NLS_MonoExtN_4	320	327			322		view
P01106	Myc proto-oncogene protein	MYC	TRG_NLS_MonoExtC_3	322	328			322		view
P01106	Myc proto-oncogene protein	MYC	MOD_GSK3_1	55	62	+1, +4		61	57	view
P01100	Proto-oncogene c-Fos	FOS	LIG_KEPE_2	264	271			264		view
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	GGA1	TRG_LysEnd_GGAAcLL_2	355	362			354		view
P31751	RAC-beta serine/threonine-protein kinase	AKT2	LIG_AGCK_PIF_1	470	475	+0, +2		473, 474		view
P17483	Homeobox protein Hox-B4	HOXB4	LIG_HOMEOBOX	142	145			141		view
P13051	Uracil-DNA glycosylase	UNG	LIG_PCNA_PIPBox_1	4	13	+0	4, 11	5, 7		view
P05556	Integrin beta-1	ITGB1	LIG_PTB_Apo_2	777	784	+0, +3, +4	776, 783	782		view
P05556	Integrin beta-1	ITGB1	LIG_PTB_Apo_2	789	796	-1, +1	788, 793	794		view
Q9BYG3	MKI67 FHA domain-interacting nucleolar phosphoprotein	MKI67IP	MOD_GSK3_1	227	234	+3, +5	226	233	229	view
Q9BYG3	MKI67 FHA domain-interacting nucleolar phosphoprotein	MKI67IP	MOD_GSK3_1	231	238	-1, +1		237	233	view
O43521	Bcl-2-like protein 11	BCL2L11	LIG_Dynein_DLC8_1	110	116	+1		115		view
O43524	Forkhead box protein O3	FOXO3	LIG_14-3-3_3	29	34			29	31	view
Q14511	Enhancer of filamentation 1	NEDD9	LIG_SH2_SRC	629	632			630	628	view
Q9Y463	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	DYRK1B	MOD_TYR_DYR	267	277			270, 275	272	view
P16104	Histone H2A.x	H2AFX	LIG_BRCT_MDC1_1	139	143			142	139	view
P04921	Glycophorin-C	GYPC	LIG_PDZ_Class_2	123	128			125		view
P02786	Transferrin receptor protein 1	TFRC	TRG_ENDOCYTIC_2	20	23	-1, +0	20	19		view
P07947	Tyrosine-protein kinase Yes	YES1	MOD_TYR_CSK	533	541			532	536	view
O95863	Zinc finger protein SNAI1	SNAI1	MOD_GSK3_1	93	100	-1, +3		99	95	view
P07550	Beta-2 adrenergic receptor	ADRB2	LIG_PDZ_Class_1	408	413	-1	407	410		view
P25911	Tyrosine-protein kinase Lyn	Lyn	MOD_TYR_CSK	504	512			503	507	view
P06213	Insulin receptor	INSR	LIG_SH2_STAT5	1361	1364			1361	1360	view
Q62318	Transcription intermediary factor 1-beta	Trim28	LIG_HP1_1	486	490			488		view
Q01196	Runt-related transcription factor 1	RUNX1	LIG_WRPW_1	450	453			452		view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	-1		213	215	view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_APCC_KENbox_2	150	154			150		view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	-1		213	215	view
Q15596	Nuclear receptor coactivator 2	NCOA2	LIG_NRBOX	640	646			639		view
P20065	Thymosin beta-4	Tmsb4x	LIG_Actin_WH2_2	9	27	-1, +1	9, 20	26		view
P67999	Ribosomal protein S6 kinase beta-1	Rps6kb1	LIG_AGCK_PIF_1	408	413			411		view
Q9BVK6	Transmembrane emp24 domain-containing protein 9	TMED9	TRG_ER_diLys_1	232	235			231		view
Q15054	DNA polymerase delta subunit 3	POLD3	LIG_PCNA_PIPBox_1	456	465			457		view
P11279	Lysosome-associated membrane glycoprotein 1	LAMP1	TRG_ENDOCYTIC_2	414	417			413		view
P50542	Peroxisomal targeting signal 1 receptor	PEX5	TRG_PEX	159	163			162		view
P50542	Peroxisomal targeting signal 1 receptor	PEX5	TRG_PEX	184	188		184	187		view
P50542	Peroxisomal targeting signal 1 receptor	PEX5	TRG_PEX	308	312		309	311		view
O95997	Securin	PTTG1	LIG_APCC_KENbox_2	8	12	+3		8		view
O15350	Tumor protein p73	TP73	TRG_NLS_Bipartite_1	327	349		330	326, 344		view
Q8IX07	Zinc finger protein ZFPM1	ZFPM1	LIG_CtBP_PxDLS_1	794	798			797		view
Q9WTQ5	A-kinase anchor protein 12	Akap12	LIG_CYCLIN_1	501	504	+0, +1, +2		500		view
Q9UBP0	Spastin	SPAST	TRG_NLS_MonoExtN_4	7	13			9, 10		view
Q9UIB8	SLAM family member 5	CD84	MOD_TYR_ITSM	312	319		316	313	315	view
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	NFATC1	LIG_KEPE_2	348	356			348		view
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	NFATC1	LIG_KEPE_2	701	708	+0		701		view
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	NFATC1	LIG_KEPE_2	913	921	-1		913		view
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	NFATC1	MOD_GSK3_1	238	245			244		view
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	NFATC1	MOD_GSK3_1	287	294			293		view
P01112	GTPase HRas	HRAS	MOD_SPalmitoyl_2	180	186			182		view
P11021	78 kDa glucose-regulated protein	HSPA5	TRG_ER_KDEL_1	651	654			650		view
P06241	Tyrosine-protein kinase Fyn	FYN	MOD_TYR_CSK	527	535			526	530	view