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Predicted switches in the ELMs Resource


General :OverviewVisualisationStatistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificityCompetitionDomain hidingMotif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : AllosteryPhysicochemical compatibilityPre-translationalDefinedPTM-induced


Cumulative - Rheostatic

Rheostatic switches gradually alter the affinity of a motif for a single binding partner by addition of multiple PTMs that additively contribute to this modulation. Additional modifications can either strengthen or weaken an interaction.

AccessionProteinGeneMotifStartStopFlankingOverlapDefinedModifiedVis
P31749RAC-alpha serine/threonine-protein kinaseAKT1LIG_AGCK_PIF_1469474+0, +2, +4472, 473view
Q13111Chromatin assembly factor 1 subunit ACHAF1ALIG_HP1_1238242-1240view
Q13291Signaling lymphocytic activation moleculeSLAMF1MOD_TYR_ITSM277284276278280view
P40225ThrombopoietinTHPOMOD_N-GLC_1205210+5204view
Q8C351LayilinLaynLIG_PTB_Apo_2374381380379view
Q03164Histone-lysine N-methyltransferase MLLMLLCLV_TASPASE127162722+1, +3, +5view
Q9BZ71Membrane-associated phosphatidylinositol transfer protein 3PITPNM3TRG_ER_FFAT_1294029, 30view
P16554Protein numbnumbLIG_EH_1538542-1, +0view
P32004Neural cell adhesion molecule L1L1CAMTRG_ENDOCYTIC_211761179+11175view
Q9HB71Calcyclin-binding proteinCACYBPLIG_SIAH_15967+0, +1, +3, +4view
Q9UMZ2Synergin gammaSYNRGLIG_AP_GAE_1773779-1, +5view
Q12834Cell division cycle protein 20 homologCDC20LIG_MAD2129137135128view
Q12834Cell division cycle protein 20 homologCDC20LIG_APCC_KENbox_296100+596view
Q13153Serine/threonine-protein kinase PAK 1PAK1LIG_SH3_21318+1, +2view
P30273High affinity immunoglobulin epsilon receptor subunit gammaFCER1GMOD_TYR_ITAM627965, 68, 74, 7764, 75view
Q9UIG0Tyrosine-protein kinase BAZ1BBAZ1BMOD_ProDKin_1155161+4, +5159, 160157view
P26045Tyrosine-protein phosphatase non-receptor type 3PTPN3LIG_14-3-3_3356361+5356358view
P18887DNA repair protein XRCC1XRCC1MOD_CK2_1515521+1, +3518517view
P18887DNA repair protein XRCC1XRCC1MOD_CK2_1520526-1524522view
O75122CLIP-associating protein 2CLASP2LIG_SxIP_EBH_1492502+0, +4498view
O75122CLIP-associating protein 2CLASP2LIG_SxIP_EBH_1515525+3515, 522, 524view
Q14980Nuclear mitotic apparatus protein 1NUMA1LIG_TNKBM_117421749+01743, 1748view
Q9UQF2C-Jun-amino-terminal kinase-interacting protein 1MAPK8IP1CLV_C14_Caspase3-7405409+1406, 408view
O75533Splicing factor 3B subunit 1SF3B1LIG_ULM_U2AF65_1195201-1, +1, +5194view
O75533Splicing factor 3B subunit 1SF3B1LIG_ULM_U2AF65_1289294+1, +4view
O75533Splicing factor 3B subunit 1SF3B1LIG_ULM_U2AF65_1333339-1, +1, +4332view
Q9BPZ3Polyadenylate-binding protein-interacting protein 2PAIP2LIG_PAM2_1109121+1, +2115view
O95600Krueppel-like factor 8KLF8LIG_CtBP_PxDLS_18690+2, +4view
Q9H4A3Serine/threonine-protein kinase WNK1WNK1LIG_SPAK-OSR1_119571961+11958view
P78314SH3 domain-binding protein 2SH3BP2LIG_TNKBM_1414421+5415view
P60484Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTENCLV_C14_Caspase3-7381385-1381, 382, 384view
P60484Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTENMOD_CK2_1382388381, 382384view
P06400Retinoblastoma-associated proteinRB1LIG_CYCLIN_1873877+4873872view
P06400Retinoblastoma-associated proteinRB1TRG_NLS_Bipartite_1860877+4872, 873view
P06400Retinoblastoma-associated proteinRB1CLV_C14_Caspase3-7346350+2, +5346, 349view
P06400Retinoblastoma-associated proteinRB1LIG_PP1872878+3872873view
P35568Insulin receptor substrate 1IRS1LIG_14-3-3_3267272+0, +1267, 271269view
P62024Phosphatase and actin regulator 1Phactr1LIG_Actin_RPEL_3500519+5508504view
Q99661Kinesin-like protein KIF2CKIF2CLIG_SxIP_EBH_193104+1, +494view
Q05397Focal adhesion kinase 1PTK2LIG_SH3_2712717+2, +4view
Q9BZ72Membrane-associated phosphatidylinositol transfer protein 2PITPNM2TRG_ER_FFAT_1339350+2, +4view
P05412Transcription factor AP-1JUNLIG_COP1227234-1, +4230view
P05412Transcription factor AP-1JUNLIG_MAPK_13242+536view
P05412Transcription factor AP-1JUNLIG_KEPE_3225234+4230225view
P05412Transcription factor AP-1JUNMOD_GSK3_1236243+5242238view
P04049RAF proto-oncogene serine/threonine-protein kinaseRAF1LIG_14-3-3_1256261256257, 259258view
P04049RAF proto-oncogene serine/threonine-protein kinaseRAF1LIG_14-3-3_1618623+0618620view
P09693T-cell surface glycoprotein CD3 gamma chainCD3GTRG_LysEnd_APsAcLL_1149154-1, +5view
Q9Y6I3Epsin-1EPN1TRG_AP2beta_CARGO_1402411+4, +5409view
Q07954Prolow-density lipoprotein receptor-related protein 1LRP1LIG_PTB_Apo_245014508+24506view
Q04206Transcription factor p65RELATRG_NLS_MonoExtC_3301307+0, +2, +3304view
A2ALK8Tyrosine-protein phosphatase non-receptor type 3Ptpn3LIG_14-3-3_2355361+5356358view
P05106Integrin beta-3ITGB3LIG_PTB_Phospho_1767773+3, +4, +5772view
P05106Integrin beta-3ITGB3LIG_PTB_Phospho_1779785-1778, 783784view
P05106Integrin beta-3ITGB3LIG_PTB_Apo_2767774+2, +3, +4772view
P05106Integrin beta-3ITGB3LIG_PTB_Apo_2779786-1778, 783784view
P46940Ras GTPase-activating-like protein IQGAP1IQGAP1LIG_IQ836854+0, +2view
P56817Beta-secretase 1BACE1TRG_LysEnd_APsAcLL_1495500+0497view
Q9P0K1Disintegrin and metalloproteinase domain-containing protein 22ADAM22TRG_ER_diArg_1851854+0, +2, +3view
Q9P0K1Disintegrin and metalloproteinase domain-containing protein 22ADAM22LIG_14-3-3_3854859857854856view
P05107Integrin beta-2ITGB2LIG_PTB_Apo_2760767-1759view
P05107Integrin beta-2ITGB2LIG_14-3-3_3755760758754, 755, 759757view
P26010Integrin beta-7ITGB7LIG_PTB_Apo_2772779-1, +0, +3, +4, +5778view
Q61214Dual specificity tyrosine-phosphorylation-regulated kinase 1ADyrk1aMOD_TYR_DYR315325318, 323320view
P01730T-cell surface glycoprotein CD4CD4TRG_LysEnd_APsAcLL_1434439-1, +0435view
Q9UKG1DCC-interacting protein 13-alphaAPPL1LIG_OCRL_FandH_1403415402409view
Q9Z188Dual specificity tyrosine-phosphorylation-regulated kinase 1BDyrk1bMOD_TYR_DYR267277270, 275272view
Q15797Mothers against decapentaplegic homolog 1SMAD1MOD_GSK3_1207214-1213view
P35610Sterol O-acyltransferase 1SOAT1TRG_ER_diArg_11013+0, +2view
Q96RU3Formin-binding protein 1FNBP1LIG_TNKBM_1514521+0, +1516, 520view
Q924T3DNA repair protein XRCC4Xrcc4LIG_FHA_2229235229, 234230view
P25963NF-kappa-B inhibitor alphaNFKBIALIG_SCF-TrCP1_13136+1, +531, 35view
P08581Hepatocyte growth factor receptorMETLIG_SH2_SRC13491352+2, +31348view
P08581Hepatocyte growth factor receptorMETLIG_SH2_SRC13561359-1, +51355view
P08581Hepatocyte growth factor receptorMETLIG_SH2_GRB213561359-1, +51355view
P27661Histone H2A.xH2afxMOD_PIKK_1137143136, 142139view
P52566Rho GDP-dissociation inhibitor 2ARHGDIBCLV_C14_Caspase3-71620+0, +3, +419view
Q13936Voltage-dependent L-type calcium channel subunit alpha-1CCACNA1CLIG_IQ16661685+41682view
P05067Amyloid beta A4 proteinAPPLIG_PTB_Apo_2756763760, 762756, 761view
P05067Amyloid beta A4 proteinAPPLIG_SH2_GRB2757760+0, +1, +2756view
P08592Amyloid beta A4 proteinAppLIG_PTB_Apo_2756763756, 761view
Q9UQ80Proliferation-associated protein 2G4PA2G4LIG_NRBOX353359+0, +1, +3354view
Q08999Retinoblastoma-like protein 2RBL2LIG_CYCLIN_1680684+3, +5view
Q00613Heat shock factor protein 1HSF1MOD_ProDKin_1304310-1, +3306view
Q14118DystroglycanDAG1LIG_WW_1889892-1891view
Q14118DystroglycanDAG1TRG_NLS_MonoExtN_4778783779, 781view
Q13043Serine/threonine-protein kinase 4STK4TRG_NES_CRM1_1359374+5359366view
Q13043Serine/threonine-protein kinase 4STK4CLV_C14_Caspase3-7323327+1326view
P84022Mothers against decapentaplegic homolog 3SMAD3LIG_WW_Pin1_4205210-1, +2207view
P84022Mothers against decapentaplegic homolog 3SMAD3MOD_GSK3_1201208+4207203view
P35251Replication factor C subunit 1RFC1LIG_Rb_LxCxE_1663667+2, +4view
P29590Protein PMLPMLLIG_WW_Pin1_4400405-1, +2, +3399, 400402view
P29590Protein PMLPMLLIG_WW_Pin1_4502507+4503504view
P29590Protein PMLPMLLIG_WW_Pin1_4524529+0, +5526view
P00533Epidermal growth factor receptorEGFRLIG_SH2_SRC11251128+1, +21124view
Q9UER7Death domain-associated protein 6DAXXLIG_WW_Pin1_4175180-1, +3175177view
P35222Catenin beta-1CTNNB1MOD_PKA_1549555+0550551view
Q9NWV8BRISC and BRCA1-A complex member 1BABAM1LIG_TNKBM_1273426, 28view
Q9NWV8BRISC and BRCA1-A complex member 1BABAM1LIG_TNKBM_14754+246, 48view
P03129Protein E7E7LIG_Rb_LxCxE_12226+4, +5view
P49137MAP kinase-activated protein kinase 2MAPKAPK2TRG_NES_CRM1_1354368-1366view
P26599Polypyrimidine tract-binding protein 1PTBP1MOD_PKA_11319-1, +1, +215view
Q6UWZ7BRCA1-A complex subunit AbraxasFAM175ALIG_BRCT_BRCA1_1405409-1407405view
P53350Serine/threonine-protein kinase PLK1PLK1LIG_APCC_Dbox_1336344-1337, 340view
P04150Glucocorticoid receptorNR3C1MOD_SUMO292295+0, +5292view
P12931Proto-oncogene tyrosine-protein kinase SrcSRCMOD_TYR_CSK526534-1525529view
P12931Proto-oncogene tyrosine-protein kinase SrcSRCMOD_CDK_1727871, 7374view
P04637Cellular tumor antigen p53TP53LIG_CYCLIN_1381385+0, +1381380view
P04637Cellular tumor antigen p53TP53MOD_SUMO385388+3386385view
P04637Cellular tumor antigen p53TP53LIG_MDM21926-119view
P04637Cellular tumor antigen p53TP53TRG_NES_CRM1_1339352+4350view
P04637Cellular tumor antigen p53TP53MOD_PIKK_11218+11714view
P04637Cellular tumor antigen p53TP53LIG_USP7_1359363+2361view
P04637Cellular tumor antigen p53TP53LIG_USP7_1364368+1, +2, +3, +4365view
P04637Cellular tumor antigen p53TP53TRG_NLS_Bipartite_1305323+3311, 312, 313, 314304, 318, 319, 320view
P04637Cellular tumor antigen p53TP53LIG_WW_Pin1_4312317+1, +2, +3311, 312, 313314view
Q13813Spectrin alpha chain, non-erythrocytic 1SPTAN1CLV_C14_Caspase3-711821186+0, +1, +31183, 1185view
Q60591Nuclear factor of activated T-cells, cytoplasmic 2Nfatc2LIG_PP2B_1110116109115view
O15392Baculoviral IAP repeat-containing protein 5BIRC5MOD_PKA_21723222019view
O88485Cytoplasmic dynein 1 intermediate chain 1Dync1i1LIG_Dynein_DLC8_1149155-1, +3149152, 154view
P01130Low-density lipoprotein receptorLDLRLIG_PTB_Apo_2822829+0827view
Q14114Low-density lipoprotein receptor-related protein 8LRP8LIG_PTB_Apo_2860867+0865view
P24864G1/S-specific cyclin-E1CCNE1MOD_GSK3_1392399-1398394view
Q16644MAP kinase-activated protein kinase 3MAPKAPK3TRG_NLS_MonoCore_2363368+3, +4, +5view
P12023Amyloid beta A4 proteinAppLIG_PTB_Apo_2756763756, 761view
O14757Serine/threonine-protein kinase Chk1CHEK1MOD_PIKK_1314320-1314, 315316view
P26678Cardiac phospholambanPLNTRG_ER_diArg_11214+1, +2view
Q13627Dual specificity tyrosine-phosphorylation-regulated kinase 1ADYRK1AMOD_TYR_DYR315325318, 323320view
Q05586Glutamate [NMDA] receptor subunit zeta-1GRIN1TRG_ER_diArg_1893895+0, +1, +4, +5view
Q05586Glutamate [NMDA] receptor subunit zeta-1GRIN1MOD_PKA_1894900+0, +1895, 899896view
O96017Serine/threonine-protein kinase Chk2CHEK2MOD_PIKK_16571+164, 6667view
O96017Serine/threonine-protein kinase Chk2CHEK2LIG_FHA_16672-1, +06667view
P56524Histone deacetylase 4HDAC4LIG_14-3-3_3629634+1, +3632631view
P56524Histone deacetylase 4HDAC4LIG_KEPE_2558566564558view
Q8BUV3GephyrinGphnLIG_WW_Pin1_4191196+1, +2, +3193view
Q8BUV3GephyrinGphnLIG_WW_Pin1_4197202+2197, 198199view
P55210Caspase-7CASP7LIG_BIR_III_22327+1, +2view
P52701DNA mismatch repair protein Msh6MSH6LIG_PCNA_PIPBox_1413+07, 8view
P14142Solute carrier family 2, facilitated glucose transporter member 4Slc2a4TRG_LysEnd_APsAcLL_1485490485, 487view
P54253Ataxin-1ATXN1LIG_ULM_U2AF65_1770775+0774view
P54253Ataxin-1ATXN1TRG_NLS_MonoCore_2769774+0, +1view
Q8WUM4Programmed cell death 6-interacting proteinPDCD6IPLIG_PTAP_UEV_1716721+2, +5717view
P19491Glutamate receptor 2Gria2LIG_PDZ_Class_2878883879, 881view
P16070CD44 antigenCD44TRG_LysEnd_APsAcLL_1708713+1, +4view
P38398Breast cancer type 1 susceptibility proteinBRCA1TRG_NLS_MonoExtN_4606611+3, +4, +5view
P38398Breast cancer type 1 susceptibility proteinBRCA1TRG_NLS_MonoExtN_4501508+0, +1view
P38398Breast cancer type 1 susceptibility proteinBRCA1TRG_NLS_MonoExtC_3502507+1, +2view
P38398Breast cancer type 1 susceptibility proteinBRCA1TRG_NLS_MonoCore_2502507+1, +2view
P07948Tyrosine-protein kinase LynLYNMOD_SPalmitoyl_417+1, +3, +5view
P11387DNA topoisomerase 1TOP1LIG_KEPE_2116123+1116view
P54259Atrophin-1ATN1CLV_C14_Caspase3-7106110+1106view
P38936Cyclin-dependent kinase inhibitor 1CDKN1ALIG_PCNA_PIPBox_1144153+0144, 152145view
P38936Cyclin-dependent kinase inhibitor 1CDKN1ALIG_CRL4_Cdt2_1145157+3, +5144, 145, 152, 153view
P38936Cyclin-dependent kinase inhibitor 1CDKN1ATRG_NLS_Bipartite_1142158-1, +2, +4144, 145152, 153view
O60934NibrinNBNMOD_PIKK_1340346+0340342view
O35274Neurabin-2Ppp1r9bMOD_PKA_29197+1, +293view
P10636Microtubule-associated protein tauMAPTLIG_SH3_1547553+0, +1, +4547, 551view
Q9HC98Serine/threonine-protein kinase Nek6NEK6LIG_WW_Pin1_4212217211, 212214view
Q06124Tyrosine-protein phosphatase non-receptor type 11PTPN11LIG_SH2_GRB2546549+2546545view
Q13541Eukaryotic translation initiation factor 4E-binding protein 1EIF4EBP1LIG_eIF4E_15460+453view
Q13542Eukaryotic translation initiation factor 4E-binding protein 2EIF4EBP2LIG_eIF4E_15460+453view
P01106Myc proto-oncogene proteinMYCLIG_SCF_FBW7_15562+1, +457, 61view
P01106Myc proto-oncogene proteinMYCMOD_GSK3_15562+1, +46157view
P01106Myc proto-oncogene proteinMYCLIG_WW_Pin1_45560+1, +357view
P01106Myc proto-oncogene proteinMYCLIG_SH3_26065+1, +561, 63view
O00221NF-kappa-B inhibitor epsilonNFKBIELIG_SCF-TrCP1_1156161-1, +2156, 160view
P31751RAC-beta serine/threonine-protein kinaseAKT2LIG_AGCK_PIF_1470475+0, +2473, 474view
P13051Uracil-DNA glycosylaseUNGLIG_PCNA_PIPBox_1413+04, 115, 7view
P13051Uracil-DNA glycosylaseUNGLIG_SCF_FBW7_15864+26259, 63view
P05556Integrin beta-1ITGB1LIG_PTB_Apo_2777784+0, +3, +4776, 783782view
P05556Integrin beta-1ITGB1LIG_PTB_Apo_2789796-1, +1788, 793794view
Q9BYG3MKI67 FHA domain-interacting nucleolar phosphoproteinMKI67IPMOD_GSK3_1227234+3, +5226233229view
Q9BYG3MKI67 FHA domain-interacting nucleolar phosphoproteinMKI67IPMOD_GSK3_1231238-1, +1237233view
O43521Bcl-2-like protein 11BCL2L11LIG_Dynein_DLC8_1110116+1115view
P11942T-cell surface glycoprotein CD3 gamma chainCd3gTRG_LysEnd_APsAcLL_1149154-1, +5149view
Q05655Protein kinase C delta typePRKCDCLV_C14_Caspase3-7326330+0, +2, +3, +5view
Q9Y463Dual specificity tyrosine-phosphorylation-regulated kinase 1BDYRK1BMOD_TYR_DYR267277270, 275272view
Q9NY61Protein AATFAATFLIG_WW_Pin1_4143148+4142view
P16109P-selectinSELPLIG_PTB_Apo_2820827+1821view
P02786Transferrin receptor protein 1TFRCTRG_ENDOCYTIC_22023-1, +02019view
O95863Zinc finger protein SNAI1SNAI1MOD_GSK3_193100-1, +39995view
P07550Beta-2 adrenergic receptorADRB2LIG_PDZ_Class_1408413-1407410view
P10242Transcriptional activator MybMYBMOD_SUMO526529+2, +4526view
Q14694Ubiquitin carboxyl-terminal hydrolase 10USP10LIG_PAM2_18193+180, 81view
Q53EL6Programmed cell death protein 4PDCD4LIG_SCF-TrCP1_17076+1, +3, +570, 75view
Q9UQL6Histone deacetylase 5HDAC5LIG_CtBP_PxDLS_15660-1, +5view
Q92835Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1INPP5DLIG_PTB_Phospho_110161022+1, +3, +41021view
P19419ETS domain-containing protein Elk-1ELK1LIG_MAPK_1312321+2, +4view
P30307M-phase inducer phosphatase 3CDC25CLIG_14-3-3_3213218-1213215view
P30307M-phase inducer phosphatase 3CDC25CLIG_14-3-3_3213218-1213215view
P30307M-phase inducer phosphatase 3CDC25CTRG_NES_CRM1_1189203+3, +5190, 197view
P12830Cadherin-1CDH1CLV_C14_Caspase3-7747751+1, +2, +3view
Q15596Nuclear receptor coactivator 2NCOA2LIG_NRBOX689695+2, +3view
Q15596Nuclear receptor coactivator 2NCOA2MOD_SUMO730733+2, +4, +5730view
P20065Thymosin beta-4Tmsb4xLIG_Actin_WH2_2927-1, +19, 2026view
Q07889Son of sevenless homolog 1SOS1MOD_ProDKin_1116411701165, 11681166view
Q07889Son of sevenless homolog 1SOS1MOD_ProDKin_111901196+011891192view
P12956X-ray repair cross-complementing protein 6XRCC6LIG_HP1_1352356-1, +0, +1view
Q9BVK6Transmembrane emp24 domain-containing protein 9TMED9TRG_Golgi_diPhe_1221235225, 231view
Q8BT07Centrosomal protein of 55 kDaCep55LIG_WW_Pin1_4423428+5422, 427425view
Q8BT07Centrosomal protein of 55 kDaCep55LIG_WW_Pin1_4420425+0, +2422view
Q9GZX7Activation-induced cytidine deaminaseAICDAMOD_PKA_13541+14037view
Q12972Nuclear inhibitor of protein phosphatase 1PPP1R8LIG_PP1198204198, 203view
P09629Homeobox protein Hox-B7HOXB7LIG_HOMEOBOX127130+1, +2view
P50542Peroxisomal targeting signal 1 receptorPEX5TRG_PEX184188184187view
P50542Peroxisomal targeting signal 1 receptorPEX5TRG_PEX308312309311view
O95997SecurinPTTG1LIG_APCC_KENbox_2812+38view
O15350Tumor protein p73TP73LIG_MDM21522+4, +5view
O15350Tumor protein p73TP73TRG_NLS_Bipartite_1327349330326, 344view
Q9WTQ5A-kinase anchor protein 12Akap12LIG_CYCLIN_1501504+0, +1, +2500view
Q9BY41Histone deacetylase 8HDAC8MOD_PKA_13642+0, +538view
P18827Syndecan-1SDC1LIG_PDZ_Class_2305310-1308view
Q96GD4Aurora kinase BAURKBLIG_APCC_KENbox_237+0, +46view
Q9UBP0SpastinSPASTTRG_NLS_MonoExtN_47139, 10view
Q9UIB8SLAM family member 5CD84MOD_TYR_ITSM275282+2279, 280278view
Q9UIB8SLAM family member 5CD84MOD_TYR_ITSM312319316313315view
O95644Nuclear factor of activated T-cells, cytoplasmic 1NFATC1LIG_KEPE_2701708+0701view
O95644Nuclear factor of activated T-cells, cytoplasmic 1NFATC1LIG_KEPE_2913921-1913view
           
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