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Predicted switches in the ELMs Resource


General :OverviewVisualisationStatistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificityCompetitionDomain hidingMotif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : AllosteryPhysicochemical compatibilityPre-translationalDefinedPTM-induced


Specificity - Domain hiding

A domain can be sterically masked by binding of an effector when there is a large difference in intrinsic affinity of the domain for different binding partners, or a large difference in the local abundance of these partners, thereby precluding further interactions of the domain. Binding of the masking molecule can be PTM-dependent or -independent.

AccessionProteinGeneMotifStartStopVis
Q8R4T5General receptor for phosphoinositides 1-associated scaffold proteinGraspLIG_PDZ_Class_1389394view
Q06187Tyrosine-protein kinase BTKBTKLIG_SH3_1186192view
Q06187Tyrosine-protein kinase BTKBTKLIG_SH3_1200206view
Q8IZP0Abl interactor 1ABI1LIG_SH3_5417421view
P08631Tyrosine-protein kinase HCKHCKLIG_SH3_4248255view
Q8TEU7Rap guanine nucleotide exchange factor 6RAPGEF6LIG_PDZ_Class_115961601view
P12931Proto-oncogene tyrosine-protein kinase SrcSRCLIG_SH3_4252259view
P12931Proto-oncogene tyrosine-protein kinase SrcSRCLIG_SH2_SRC530533view
Q60787Lymphocyte cytosolic protein 2Lcp2LIG_SH2_SRC145148view
Q06124Tyrosine-protein phosphatase non-receptor type 11PTPN11LIG_SH2_GRB2546549view
Q02410Amyloid beta A4 precursor protein-binding family A member 1APBA1LIG_PDZ_Class_2832837view
P29353SHC-transforming protein 1SHC1LIG_SH2_GRB2349352view
P29353SHC-transforming protein 1SHC1LIG_SH2_GRB2427430view
P06241Tyrosine-protein kinase FynFYNLIG_SH2_SRC531534view
           
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