switches.ELM

Predicted switches in the ELMs Resource

General :Overview Visualisation Statistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificity Competition Domain hiding Motif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : Allostery Physicochemical compatibility Pre-translational Defined PTM-induced

Specificity - Motif hiding

Motif hiding occurs when there is a large difference in intrinsic affinity of overlapping or adjacent motifs for their respective binding partners, or a large difference in the local abundance of these partners. Binding of an effector to one motif sterically masks the overlapping or adjacent motif, thereby precluding it from binding. Binding of the masking molecule can be PTM-dependent or -independent.

Accession	Protein	Gene	Motif	Start	Stop	Vis
P31749	RAC-alpha serine/threonine-protein kinase	AKT1	LIG_AGCK_PIF_1	469	474	view
P31749	RAC-alpha serine/threonine-protein kinase	AKT1	LIG_WW_Pin1_4	447	452	view
P07567	Gag polyprotein	gag	LIG_WW_1	202	205	view
P07567	Gag polyprotein	gag	LIG_PTAP_UEV_1	209	214	view
Q05128	Matrix protein VP40	VP40	LIG_PTAP_UEV_1	6	11	view
Q05128	Matrix protein VP40	VP40	LIG_WW_1	10	13	view
O73557	RING finger protein Z	Z	LIG_WW_1	94	97	view
O73557	RING finger protein Z	Z	LIG_PTAP_UEV_1	80	85	view
P03345	Gag polyprotein	gag	LIG_WW_1	118	121	view
P03345	Gag polyprotein	gag	LIG_PTAP_UEV_1	123	128	view
P16471	Prolactin receptor	PRLR	LIG_SH2_STAT5	342	345	view
P16471	Prolactin receptor	PRLR	LIG_SCF-TrCP1_1	348	353	view
P06400	Retinoblastoma-associated protein	RB1	LIG_CYCLIN_1	873	877	view
P06400	Retinoblastoma-associated protein	RB1	TRG_NLS_Bipartite_1	860	877	view
P06400	Retinoblastoma-associated protein	RB1	LIG_PP1	872	878	view
P05412	Transcription factor AP-1	JUN	LIG_COP1	227	234	view
P05412	Transcription factor AP-1	JUN	LIG_MAPK_1	32	42	view
P05412	Transcription factor AP-1	JUN	LIG_KEPE_3	225	234	view
P05412	Transcription factor AP-1	JUN	LIG_SCF_FBW7_1	236	243	view
P05412	Transcription factor AP-1	JUN	LIG_WW_Pin1_4	60	65	view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Phospho_1	4467	4473	view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Phospho_1	4501	4507	view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Apo_2	4467	4474	view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Apo_2	4501	4508	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Phospho_1	767	773	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Phospho_1	779	785	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Apo_2	767	774	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Apo_2	779	786	view
Q99741	Cell division control protein 6 homolog	CDC6	LIG_CYCLIN_1	94	98	view
Q99741	Cell division control protein 6 homolog	CDC6	LIG_APCC_KENbox_2	80	84	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	831	836	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	TRG_ER_diArg_1	851	854	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	854	859	view
P05107	Integrin beta-2	ITGB2	LIG_PTB_Apo_2	760	767	view
P05107	Integrin beta-2	ITGB2	LIG_14-3-3_3	755	760	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_SRC	1349	1352	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_SRC	1356	1359	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_GRB2	1356	1359	view
Q8R4T5	General receptor for phosphoinositides 1-associated scaffold protein	Grasp	LIG_PDZ_Class_1	389	394	view
P08363	Non-structural protein P8	S10	LIG_PTAP_UEV_1	40	45	view
P08363	Non-structural protein P8	S10	LIG_WW_1	36	39	view
P69616	Protein ORF3	None	LIG_PTAP_UEV_1	95	100	view
P69616	Protein ORF3	None	LIG_SH3_3	102	108	view
Q06187	Tyrosine-protein kinase BTK	BTK	LIG_SH3_1	186	192	view
Q06187	Tyrosine-protein kinase BTK	BTK	LIG_SH3_1	200	206	view
P05067	Amyloid beta A4 protein	APP	LIG_PTB_Apo_2	756	763	view
P05067	Amyloid beta A4 protein	APP	LIG_SH2_GRB2	757	760	view
P05067	Amyloid beta A4 protein	APP	LIG_WW_Pin1_4	740	745	view
Q8IZP0	Abl interactor 1	ABI1	LIG_SH3_5	417	421	view
Q14118	Dystroglycan	DAG1	LIG_WW_1	889	892	view
Q14118	Dystroglycan	DAG1	LIG_SH2_SRC	892	895	view
P03230	Latent membrane protein 1	LMP1	LIG_SCF-TrCP1_1	210	215	view
P03230	Latent membrane protein 1	LMP1	LIG_TRAF2_2	204	209	view
P08631	Tyrosine-protein kinase HCK	HCK	LIG_SH3_4	248	255	view
P04233	HLA class II histocompatibility antigen gamma chain	CD74	TRG_LysEnd_APsAcLL_1	19	24	view
P04233	HLA class II histocompatibility antigen gamma chain	CD74	TRG_ER_diArg_1	3	5	view
P04233	HLA class II histocompatibility antigen gamma chain	CD74	LIG_14-3-3_3	5	10	view
P09793	Cytotoxic T-lymphocyte protein 4	Ctla4	TRG_ENDOCYTIC_2	201	204	view
P09793	Cytotoxic T-lymphocyte protein 4	Ctla4	LIG_SH2_STAT5	201	204	view
P00533	Epidermal growth factor receptor	EGFR	LIG_SH2_SRC	1016	1019	view
P00533	Epidermal growth factor receptor	EGFR	LIG_SH2_SRC	1125	1128	view
P00533	Epidermal growth factor receptor	EGFR	TRG_ENDOCYTIC_2	998	1001	view
P00533	Epidermal growth factor receptor	EGFR	LIG_PTB_Phospho_1	1104	1110	view
O88339	Epsin-1	Epn1	LIG_Clathr_ClatBox_1	480	484	view
O88339	Epsin-1	Epn1	LIG_EH_1	500	504	view
P14003	Protein hairy	h	LIG_CtBP_PxDLS_1	318	322	view
P14003	Protein hairy	h	LIG_WRPW_1	334	337	view
Q8TEU7	Rap guanine nucleotide exchange factor 6	RAPGEF6	LIG_PDZ_Class_1	1596	1601	view
P12931	Proto-oncogene tyrosine-protein kinase Src	SRC	LIG_SH3_4	252	259	view
P12931	Proto-oncogene tyrosine-protein kinase Src	SRC	LIG_SH2_SRC	530	533	view
P04637	Cellular tumor antigen p53	TP53	LIG_CYCLIN_1	381	385	view
P04637	Cellular tumor antigen p53	TP53	LIG_MDM2	19	26	view
P04637	Cellular tumor antigen p53	TP53	TRG_NES_CRM1_1	339	352	view
P04637	Cellular tumor antigen p53	TP53	LIG_USP7_1	359	363	view
P04637	Cellular tumor antigen p53	TP53	LIG_USP7_1	364	368	view
P04637	Cellular tumor antigen p53	TP53	TRG_NLS_Bipartite_1	305	323	view
P04637	Cellular tumor antigen p53	TP53	LIG_WW_Pin1_4	30	35	view
P04637	Cellular tumor antigen p53	TP53	LIG_WW_Pin1_4	312	317	view
P14598	Neutrophil cytosol factor 1	NCF1	LIG_SH3_2	363	368	view
P14598	Neutrophil cytosol factor 1	NCF1	LIG_WW_Pin1_4	342	347	view
Q60787	Lymphocyte cytosolic protein 2	Lcp2	LIG_SH2_SRC	145	148	view
P46527	Cyclin-dependent kinase inhibitor 1B	CDKN1B	LIG_SCF_Skp2-Cks1_1	183	190	view
P46527	Cyclin-dependent kinase inhibitor 1B	CDKN1B	LIG_WW_Pin1_4	184	189	view
P54253	Ataxin-1	ATXN1	LIG_14-3-3_1	772	777	view
P54253	Ataxin-1	ATXN1	LIG_ULM_U2AF65_1	770	775	view
P54253	Ataxin-1	ATXN1	TRG_NLS_MonoCore_2	769	774	view
P25942	Tumor necrosis factor receptor superfamily member 5	CD40	LIG_TRAF6	231	239	view
P25942	Tumor necrosis factor receptor superfamily member 5	CD40	LIG_TRAF2_1	250	253	view
P03322	Gag-Pro polyprotein	gag-pro	LIG_WW_1	172	175	view
P03322	Gag-Pro polyprotein	gag-pro	LIG_LYPXL_S_1	180	184	view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	LIG_PCNA_PIPBox_1	144	153	view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	LIG_CRL4_Cdt2_1	145	157	view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	TRG_NLS_Bipartite_1	142	158	view
Q15303	Receptor tyrosine-protein kinase erbB-4	ERBB4	LIG_WW_1	1053	1056	view
Q15303	Receptor tyrosine-protein kinase erbB-4	ERBB4	LIG_SH2_STAT5	1056	1059	view
P49755	Transmembrane emp24 domain-containing protein 10	TMED10	TRG_ER_diLys_1	215	219	view
P49755	Transmembrane emp24 domain-containing protein 10	TMED10	TRG_Golgi_diPhe_1	204	219	view
Q06124	Tyrosine-protein phosphatase non-receptor type 11	PTPN11	LIG_SH2_GRB2	546	549	view
P01106	Myc proto-oncogene protein	MYC	LIG_SCF_FBW7_1	55	62	view
P01106	Myc proto-oncogene protein	MYC	LIG_WW_Pin1_4	55	60	view
P01106	Myc proto-oncogene protein	MYC	LIG_SH3_2	60	65	view
P06729	T-cell surface antigen CD2	CD2	LIG_GYF	281	289	view
P06729	T-cell surface antigen CD2	CD2	LIG_GYF	295	303	view
P06729	T-cell surface antigen CD2	CD2	LIG_SH3_3	294	300	view
Q01094	Transcription factor E2F1	E2F1	LIG_CYCLIN_1	90	94	view
Q01094	Transcription factor E2F1	E2F1	LIG_HCF-1_HBM_1	97	100	view
P03070	Large T antigen	None	LIG_Rb_LxCxE_1	103	107	view
P03070	Large T antigen	None	TRG_NLS_MonoCore_2	127	132	view
P03070	Large T antigen	None	TRG_NLS_MonoExtC_3	127	133	view
P03070	Large T antigen	None	TRG_NLS_MonoExtN_4	126	132	view
Q02410	Amyloid beta A4 precursor protein-binding family A member 1	APBA1	LIG_PDZ_Class_2	832	837	view
P51519	Envelope glycoprotein	env	TRG_ENDOCYTIC_2	487	490	view
P51519	Envelope glycoprotein	env	TRG_LysEnd_APsAcLL_1	463	468	view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	view
P30307	M-phase inducer phosphatase 3	CDC25C	TRG_NES_CRM1_1	189	203	view
Q9U1K1	Protein spire	spir	LIG_Actin_WH2_2	432	448	view
Q9U1K1	Protein spire	spir	LIG_Actin_WH2_1	464	480	view
P29353	SHC-transforming protein 1	SHC1	LIG_SH2_GRB2	349	352	view
P29353	SHC-transforming protein 1	SHC1	LIG_SH2_GRB2	427	430	view
Q9BVK6	Transmembrane emp24 domain-containing protein 9	TMED9	TRG_ER_diLys_1	232	235	view
Q9BVK6	Transmembrane emp24 domain-containing protein 9	TMED9	TRG_Golgi_diPhe_1	221	235	view
O15350	Tumor protein p73	TP73	LIG_SH3_3	407	413	view
O15350	Tumor protein p73	TP73	TRG_NES_CRM1_1	366	379	view
O15350	Tumor protein p73	TP73	TRG_NLS_Bipartite_1	327	349	view
O15350	Tumor protein p73	TP73	LIG_WW_Pin1_4	409	414	view
Q91841	Translocon-associated protein	None	TRG_Golgi_diPhe_1	190	205	view
Q91841	Translocon-associated protein	None	TRG_ER_diLys_1	201	205	view
P06241	Tyrosine-protein kinase Fyn	FYN	LIG_SH2_SRC	531	534	view