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IPR:IPR000980 (23 hits)
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Index
Epidermal growth factor receptor
Non-receptor tyrosine-protein kinase TYK2
Proto-oncogene tyrosine-protein kinase Src
Receptor tyrosine-protein kinase erbB-2
Tyrosine-protein kinase ABL1
Tyrosine-protein kinase Lck
Tyrosine-protein kinase ZAP-70
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
Epidermal growth factor receptor -
EGFR
-  
Homo sapiens
LIG_SH2_IE
EGFR_HUMAN
1011
1020
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Ras and Rab interactor 1 (RIN1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1191
1200
Binary
Physicochemical compatibility
Phosphorylation of Y1197 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Ras and Rab interactor 1 (RIN1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1191
1200
Binary
Physicochemical compatibility
Phosphorylation of Y1197 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Ras and Rab interactor 1 (RIN1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1008
1024
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Tyrosine-protein kinase JAK1 (JAK1)
protein.
details
Inferred
Non-receptor tyrosine-protein kinase TYK2 -
TYK2
-  
Homo sapiens
LIG_SH2_IE
INAR1_HUMAN
458
474
Binary
Physicochemical compatibility
Phosphorylation of Y466 in the SH2-binding motif of
Interferon alpha/beta receptor 1 (IFNAR1)
induces binding to the
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
protein.
details
Inferred
LIG_SH2_IE
INAR1_HUMAN
458
474
Binary
Physicochemical compatibility
Phosphorylation of Y466 in the SH2-binding motif of
Interferon alpha/beta receptor 1 (IFNAR1)
induces binding to the
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
protein.
details
Inferred
LIG_SH2_IE
INAR1_HUMAN
458
474
Binary
Physicochemical compatibility
Phosphorylation of Y466 in the SH2-binding motif of
Interferon alpha/beta receptor 1 (IFNAR1)
induces binding to the
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
protein.
details
Inferred
LIG_SH2_IE
INAR1_HUMAN
473
489
Binary
Physicochemical compatibility
Phosphorylation of Y481 in the SH2-binding motif of
Interferon alpha/beta receptor 1 (IFNAR1)
induces binding to the
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
protein.
details
Inferred
LIG_SH2_IE
INAR1_HUMAN
473
489
Binary
Physicochemical compatibility
Phosphorylation of Y481 in the SH2-binding motif of
Interferon alpha/beta receptor 1 (IFNAR1)
induces binding to the
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
protein.
details
Inferred
Proto-oncogene tyrosine-protein kinase Src -
SRC
-  
Homo sapiens
LIG_SH2_IE
EGFR_HUMAN
1011
1020
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Ras and Rab interactor 1 (RIN1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1011
1020
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Ras and Rab interactor 1 (RIN1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1008
1024
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Tyrosine-protein kinase JAK1 (JAK1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1008
1024
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Tyrosine-protein kinase JAK1 (JAK1)
protein.
details
Inferred
Receptor tyrosine-protein kinase erbB-2 -
ERBB2
-  
Homo sapiens
LIG_SH2_IE
ERBB2_HUMAN
1015
1031
Binary
Physicochemical compatibility
Phosphorylation of Y1023 in the SH2-binding motif of
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
induces binding to the
Tyrosine-protein kinase JAK1 (JAK1)
protein.
details
Inferred
Tyrosine-protein kinase ABL1 -
ABL1
-  
Homo sapiens
LIG_SH2_IE
EGFR_HUMAN
1011
1020
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Ras and Rab interactor 1 (RIN1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1191
1200
Binary
Physicochemical compatibility
Phosphorylation of Y1197 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Ras and Rab interactor 1 (RIN1)
protein.
details
Inferred
LIG_SH2_IE
EGFR_HUMAN
1008
1024
Binary
Physicochemical compatibility
Phosphorylation of Y1016 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Tyrosine-protein kinase JAK1 (JAK1)
protein.
details
Inferred
Tyrosine-protein kinase Lck -
LCK
-  
Homo sapiens
LIG_SH2_IIC
ZAP70_HUMAN
284
300
Binary
Physicochemical compatibility
Phosphorylation of Y292 in the SH2-binding motif of
Tyrosine-protein kinase ZAP-70 (ZAP70)
induces binding to the
E3 ubiquitin-protein ligase CBL-B (CBLB)
protein.
details
Inferred
LIG_SH2_IIC
ZAP70_HUMAN
284
300
Binary
Physicochemical compatibility
Phosphorylation of Y292 in the SH2-binding motif of
Tyrosine-protein kinase ZAP-70 (ZAP70)
induces binding to the
E3 ubiquitin-protein ligase CBL-B (CBLB)
protein.
details
Inferred
LIG_SH2_IIC
ZAP70_HUMAN
284
300
Binary
Physicochemical compatibility
Phosphorylation of Y292 in the SH2-binding motif of
Tyrosine-protein kinase ZAP-70 (ZAP70)
induces binding to the
E3 ubiquitin-protein ligase CBL-B (CBLB)
protein.
details
Inferred
Tyrosine-protein kinase ZAP-70 -
ZAP70
-  
Homo sapiens
LIG_SH2_IIC
ZAP70_HUMAN
284
300
Binary
Physicochemical compatibility
Phosphorylation of Y292 in the SH2-binding motif of
Tyrosine-protein kinase ZAP-70 (ZAP70)
induces binding to the
E3 ubiquitin-protein ligase CBL-B (CBLB)
protein.
details
Inferred
LIG_SH2_IIC
ZAP70_HUMAN
284
300
Binary
Physicochemical compatibility
Phosphorylation of Y292 in the SH2-binding motif of
Tyrosine-protein kinase ZAP-70 (ZAP70)
induces binding to the
E3 ubiquitin-protein ligase CBL-B (CBLB)
protein.
details
Inferred
LIG_SH2_IIC
ZAP70_HUMAN
284
300
Binary
Physicochemical compatibility
Phosphorylation of Y292 in the SH2-binding motif of
Tyrosine-protein kinase ZAP-70 (ZAP70)
induces binding to the
E3 ubiquitin-protein ligase CBL-B (CBLB)
protein.
details
Inferred